A Comparison of Dose Metrics to Predict Local Tumor Control for Photofrin-mediated Photodynamic Therapy.
A Comparison of Dose Metrics to Predict Local Tumor Control for Photofrin-mediated Photodynamic Therapy.
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DOI：
10.1111/php.12719
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发表时间：
2017-07
影响因子：
3.3
通讯作者：
Zhu TC
中科院分区：
文献类型：
--
作者：
Qiu H;Kim MM;Penjweini R;Finlay JC;Busch TM;Wang T;Guo W;Cengel KA;Simone CB 2nd;Glatstein E;Zhu TC
这项临床前研究检查了光通量、PDT剂量和“表观反应单线态氧”[1 O2] kD，以预测Photofrin介导的光动力疗法（PDT）治疗辐射诱导的纤维肉瘤（RIF）肿瘤的局部控制率（LCR）。携带RIF肿瘤的小鼠用5和15 mg/kg Photofrin剂量的空气中能量密度（50-250 J/cm 2）和空气中能量密度率（50-150 mW/cm 2）治疗，药物-光间隔为24小时，使用630 nm 1 cm直径准直激光。一个宏观模型被用来计算[1 O2] PDT剂量的基础上，在体内明确的剂量测定的药物浓度，光通量，和组织的光学特性。PDT剂量和[1 O2]半衰期分别定义为药物浓度和注量率的时间积分以及消耗的单线态氧浓度除以单线态氧寿命。对74只小鼠（66 + 8只对照）的LCR进行不同剂量度量分层。[1 O2] kD ≥ 1.1 mM或PDT剂量≥ 1200 μMJ/cm 2时，观察到14天时肿瘤完全控制，但无法单独用通量预测。LCR随[1 O2] O2和PDT剂量的增加而增加，但与注量没有很好的相关性。比较剂量学量，[1 O2] cross-performed优于PDT剂量和通量在预测肿瘤反应和相关LCR。
This preclinical study examines light fluence, PDT dose, and “apparent reacted singlet oxygen”, [1O2]rx, to predict local control rate (LCR) for Photofrin-mediated photodynamic therapy (PDT) of radiation-induced fibrosarcoma (RIF) tumors. Mice bearing RIF tumors were treated with in-air fluences (50–250 J/cm2) and in-air fluence rates (50–150 mW/cm2) at Photofrin dosages of 5 and 15 mg/kg and a drug-light interval of 24 hours using a 630nm 1-cm diameter collimated laser. A macroscopic model were used to calculate [1O2]rx and PDT dose based on in vivo explicit dosimetry of the drug concentration, light fluence, and tissue optical properties. PDT dose and [1O2]rx were defined as a temporal integral of drug concentration and fluence rate, and singlet oxygen concentration consumed divided by the singlet oxygen lifetime, respectively. LCR was stratified for different dose metrics for 74 mice (66 + 8 control). Complete tumor control at 14 days was observed for [1O2]rx ≥ 1.1 mM or PDT dose ≥ 1200 μMJ/cm2 but cannot be predicted with fluence alone. LCR increases with increasing [1O2]rx and PDT dose but is not well correlated with fluence. Comparing dosimetric quantities, [1O2]rx outperformed both PDT dose and fluence in predicting tumor response and correlating with LCR.
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影响因子：
3.3
作者：
PATTERSON, MS;WILSON, BC;GRAFF, R
通讯作者：
GRAFF, R
DOI：
10.1016/j.giec.2009.07.008
发表时间：
2010-01-01
影响因子：
--
作者：
Gross, Seth A;Wolfsen, Herbert C
通讯作者：
Wolfsen, Herbert C
影响因子：
3.5
作者：
Dimofte, A;Finlay, JC;Zhu, TC
通讯作者：
Zhu, TC
DOI：
10.1039/b9pp00004f
发表时间：
2009-12
期刊：
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology
影响因子：
--
作者：
Busch TM;Xing X;Yu G;Yodh A;Wileyto EP;Wang HW;Durduran T;Zhu TC;Wang KK
通讯作者：
Wang KK
影响因子：
2.4
作者：
Corti, Luigi;Toniolo, Lamberto;Sotti, Guido
通讯作者：
Sotti, Guido