Infrared navigation system for light dosimetry during pleural photodynamic therapy.
Infrared navigation system for light dosimetry during pleural photodynamic therapy.
复制标题
用于胸膜光动力治疗期间光剂量测定的红外导航系统。
DOI：
10.1088/1361-6560/ab7632
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发表时间：
2020-04-14
影响因子：
3.5
通讯作者：
Cengel KA
中科院分区：
文献类型：
--
作者：
Kim MM;Zhu TC;Ong YH;Finlay JC;Dimofte A;Singhal S;Glatstein E;Cengel KA
胸膜光动力疗法(PDT)用于术中治疗恶性胸膜间皮瘤患者的显微疾病。准确的光剂量传递对光动力疗法的效率至关重要。作为一项护理标准，使用8个各向同性探测器在胸腔内预先确定的离散位置将光通量传递到规定的光通量，胸腔内填充了稀释的Intralipid溶液。光学红外(IR)导航系统用于监测改进和改进的治疗输送棒上的反射被动标记，以跟踪光源在光输送期间在治疗腔内的位置。这些信息被用来计算光剂量，结合了恒定的散射光剂量，并使用了双重校正方法。对8个探测器位置和7个患者病例研究的计算方法进行了广泛的比较。通过在二维平面上表示解开的三维几何形状，量化了光通量的均匀性。将治疗结束时计算的光通量与各向同性探测器的测量值进行比较。使用所有探测器位置的恒定散射剂量以及双重校正方法，每个探测器的计算值和实测值之间的差异在15%以内。主光剂量本身并不能完全解释腔内传输的光。这对于确定在探测器位置之间传送到胸腔区域的光剂量是有用的，并且可以用于通过在外科环境中实时实施来改进治疗传送。我们得出结论，这种胸膜PDT方法的光通量均匀度的标准偏差为10%。
Pleural photodynamic therapy (PDT) is performed intraoperatively for the treatment of microscopic disease in patients with malignant pleural mesothelioma. Accurate delivery of light dose is critical to PDT efficiency. As a standard of care, light fluence is delivered to the prescribed fluence using eight isotropic detectors in pre-determined discrete locations inside the pleural cavity that is filled with a dilute Intralipid solution. An optical infrared (IR) navigation system was used to monitor reflective passive markers on a modified and improved treatment delivery wand to track the position of the light source within the treatment cavity during light delivery. This information was used to calculate the light dose, incorporating a constant scattered light dose and using a dual correction method. Calculation methods were extensively compared for eight detector locations and seven patient case studies. The light fluence uniformity was also quantified by representing the unraveled three-dimensional geometry on a two-dimensional plane. Calculated light fluence at the end of treatment delivery was compared to measured values from isotropic detectors. Using a constant scattered dose for all detector locations along with a dual correction method, the difference between calculated and measured values for each detector was within 15%. Primary light dose alone does not fully account for the light delivered inside the cavity. This is useful in determining the light dose delivered to areas of the pleural cavity between detector locations, and can serve to improve treatment delivery with implementation in real-time in the surgical setting. We concluded that the standard deviation of light fluence uniformity for this method of pleural PDT is 10%.
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对恶性胸膜间皮瘤的自由基胸膜切除术和术中光动力疗法。
影响因子：
4.6
作者：
Friedberg, Joseph S.;Culligan, Melissa J.;Mick, Rosemarie;Stevenson, James;Hahn, Stephen M.;Sterman, Daniel;Punekar, Salman;Glatstein, Eli;Cengel, Keith
通讯作者：
Cengel, Keith
影响因子：
3.5
作者：
Friedberg, Joseph S.;Cengel, Keith A.
通讯作者：
Cengel, Keith A.
影响因子：
3.8
作者：
Penjweini, Rozhin;Kim, Michele M.;Zhu, Timothy C.
通讯作者：
Zhu, Timothy C.
影响因子：
3.3
作者：
Zhu, Timothy C.;Ong, Yihong;Cengel, Keith A.
通讯作者：
Cengel, Keith A.
影响因子：
4.3
作者：
Hahn, S M;Smith, R P;Friedberg, J
通讯作者：
Friedberg, J