The variant-specific burden of SARS-CoV-2 in Michigan: March 2020 through November 2021.
The variant-specific burden of SARS-CoV-2 in Michigan: March 2020 through November 2021.
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DOI：
10.1002/jmv.27982
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发表时间：
2022-11
影响因子：
12.7
通讯作者：
Martin, Emily T.
中科院分区：
文献类型：
--
作者：
Petrie, Joshua G.;Eisenberg, Marisa C.;Lauring, Adam S.;Gilbert, Julie;Harrison, Samantha M.;DeJonge, Peter M.;Martin, Emily T.
需要准确估计严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）的总负担，以便为政策、规划和应对提供信息。我们试图量化密歇根州按年龄分类的SARS-CoV-2病例、住院和死亡。将密歇根州疾病监测系统报告的2019年冠状病毒疾病病例乘以年龄和特定时间的调整因子，以纠正检测不足。调整因素估计在一个模型拟合发病率数据和血清阳性率估计。根据公开数据估计了SARS-CoV-2住院、死亡、疫苗接种和变异比例的年龄特异性发病率。我们估计了因年龄和时间而异的大量感染检测不足。考虑到检测不足，我们估计截至2021年11月中旬，密歇根州的累计感染率达到75%，估计超过87%的密歇根州居民曾接受过≥1剂疫苗接种和/或既往感染。与大流行波相比，儿童的相对负担随着时间的推移而增加。总的来说，住院或死亡病例的比例随着时间的推移而下降。我们的研究结果强调了尽管广泛的既往感染和疫苗接种，但SARS-CoV-2高发病率时期的持续风险。这强调了在持续应对急性大流行期间，需要对监测、疫苗接种和其他缓解措施进行长期规划。
Accurate estimates of the total burden of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) are needed to inform policy, planning, and response. We sought to quantify SARS‐CoV‐2 cases, hospitalizations, and deaths by age in Michigan. Coronavirus disease 2019 cases reported to the Michigan Disease Surveillance System were multiplied by age and time‐specific adjustment factors to correct for under‐detection. Adjustment factors were estimated in a model fit to incidence data and seroprevalence estimates. Age‐specific incidence of SARS‐CoV‐2 hospitalization, death, vaccination, and variant proportions were estimated from publicly available data. We estimated substantial under‐detection of infection that varied by age and time. Accounting for under‐detection, we estimate the cumulative incidence of infection in Michigan reached 75% by mid‐November 2021, and over 87% of Michigan residents were estimated to have had ≥1 vaccination dose and/or previous infection. Comparing pandemic waves, the relative burden among children increased over time. In general, the proportion of cases who were hospitalized or who died decreased over time. Our results highlight the ongoing risk of periods of high SARS‐CoV‐2 incidence despite widespread prior infection and vaccination. This underscores the need for long‐term planning for surveillance, vaccination, and other mitigation measures amidst continued response to the acute pandemic.
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DOI：
10.1016/s1473-3099(21)00475-8
发表时间：
2022-01
期刊：
The Lancet. Infectious diseases
影响因子：
--
作者：
Twohig KA;Nyberg T;Zaidi A;Thelwall S;Sinnathamby MA;Aliabadi S;Seaman SR;Harris RJ;Hope R;Lopez-Bernal J;Gallagher E;Charlett A;De Angelis D;Presanis AM;Dabrera G;COVID-19 Genomics UK (COG-UK) consortium
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COVID-19 Genomics UK (COG-UK) consortium
DOI：
10.1097/ede.0000000000001361
发表时间：
2021-07-01
期刊：
Epidemiology (Cambridge, Mass.)
影响因子：
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作者：
Shioda K;Lau MSY;Kraay ANM;Nelson KN;Siegler AJ;Sullivan PS;Collins MH;Weitz JS;Lopman BA
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Lopman BA
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DOI：
10.1126/science.abg3055
发表时间：
2021-04-09
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Davies NG;Abbott S;Barnard RC;Jarvis CI;Kucharski AJ;Munday JD;Pearson CAB;Russell TW;Tully DC;Washburne AD;Wenseleers T;Gimma A;Waites W;Wong KLM;van Zandvoort K;Silverman JD;CMMID COVID-19 Working Group;COVID-19 Genomics UK (COG-UK) Consortium;Diaz-Ordaz K;Keogh R;Eggo RM;Funk S;Jit M;Atkins KE;Edmunds WJ
通讯作者：
Edmunds WJ
DOI：
10.1016/j.lanepe.2021.100252
发表时间：
2022-01
期刊：
The Lancet regional health. Europe
影响因子：
--
作者：
Allen H;Vusirikala A;Flannagan J;Twohig KA;Zaidi A;Chudasama D;Lamagni T;Groves N;Turner C;Rawlinson C;Lopez-Bernal J;Harris R;Charlett A;Dabrera G;Kall M;COVID-19 Genomics UK (COG-UK Consortium)
通讯作者：
COVID-19 Genomics UK (COG-UK Consortium)
影响因子：
6.4
作者：
Lewis, Nathaniel M.;Naioti, Eric A.;Tenforde, Mark W.
通讯作者：
Tenforde, Mark W.