Structural and functional organization of the lower jaw barrel subfield in rat primary somatosensory cortex.
Structural and functional organization of the lower jaw barrel subfield in rat primary somatosensory cortex.
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DOI：
10.1002/cne.25063
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发表时间：
2021-06
期刊：
影响因子：
--
通讯作者：
Waters RS
中科院分区：
文献类型：
--
作者：
Pellicer-Morata V;Wang L;de Jongh Curry A;Tsao JW;Waters RS
啮齿动物初级躯体感觉皮层的桶状亚区是研究皮层组织和重组的重要模型系统。在肢体去传入后的皮质重组过程中，去传入的前肢SI中的神经元对来自下颌骨的先前未表达的输入产生反应。虽然下巴桶子场(LJBSF)可能是输入的来源，但这个子场几乎没有受到关注。我们的目的是描述正常LJBSF的结构和功能组织。为了研究LJBSF的组织结构，建立了下颌骨皮肤表面的命名法，用细胞色素氧化酶(CO)标记平切的LJBSF切片，使用微电极标记SI中下颌骨皮肤表面的表示，并使用电极穿透恢复的电解性损伤将生理图与潜在的桶形图对齐。LJBSF是一个撕裂状的小油田，包含大约24桶，排列成八排中外侧和一个覆盖前边界的无油管区。下颌皮肤由嵌入普通毛皮的下巴触须和微触须组成，在对侧SI中以体位图的形式组织起来。这张生理图谱显示，触须的活性与潜在的LJBSF的共染色一致。LJBSF桶从下巴的单个触须和微触须接收特定于桶的地形排序的输入，而不是来自三叉戟胡须。无筒区接收来自下唇部的按地形排列的输入。这些数据表明，LJBSF是一个高度组织化的亚区，这对于理解其在皮质重组中的可能作用至关重要。
Barrel subfields in rodent primary somatosensory cortex (SI) are important model systems for studying cortical organization and reorganization. During cortical reorganization that follows limb deafferentation, neurons in deafferented forelimb SI become responsive to previously unexpressed inputs from the lower jaw. Although the lower jaw barrel subfield (LJBSF) is a likely source of the input, this subfield has received little attention. Our aim was to describe the structural and functional organization of the normal LJBSF. To investigate LJBSF organization, a nomenclature for lower jaw skin surface was developed, cytochrome oxidase (CO) was used to label flattened-cut LJBSF sections, microelectrodes were used to map the lower jaw skin surface representation in SI, and electrolytic lesions, recovered from electrode penetrations, were used to align the physiological map to the underlying barrel map. LJBSF is a tear-shaped subfield containing approximately 24 barrels, arranged in eight mediolateral rows and a barrel-free zone capping the anterior border. The representation of the lower jaw skin consisting of chin vibrissae and microvibrissae embedded in common fur is somatotopically organized in a single map in the contralateral SI. This physiological map shows that the activity from the vibrissae aligns with the CO-staining of the underlying LJBSF. LJBSF barrels receive topographically ordered barrel-specific input from individual vibrissa and microvibrissae in the lower jaw but not from trident whiskers. The barrel-free zone receives topographically ordered input from the lower lip. These data demonstrating that the LJBSF is a highly organized subfield are essential for understanding its possible role in cortical reorganization.
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影响因子：
5.7
作者：
Deschênes M;Moore J;Kleinfeld D
通讯作者：
Kleinfeld D
影响因子：
2.5
作者：
Remple, MS;Henry, EC;Catania, KC
通讯作者：
Catania, KC
影响因子：
2.7
作者：
Brecht, M;Preilowski, B;Merzenich, MM
通讯作者：
Merzenich, MM
影响因子：
4.6
作者：
Clemens, Ann M.;Delgado, Yohami Fernandez;Brecht, Michael
通讯作者：
Brecht, Michael
DOI：
10.1073/pnas.77.4.2333
发表时间：
1980-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
WONGRILEY, MTT;WELT, C
通讯作者：
WELT, C