11-deoxy prostaglandin F(2α), a thromboxane A2 receptor agonist, partially alleviates embryo crowding in Lpar3((-/-)) females.
11-deoxy prostaglandin F(2α), a thromboxane A2 receptor agonist, partially alleviates embryo crowding in Lpar3((-/-)) females.
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DOI：
10.1016/j.fertnstert.2011.12.004
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发表时间：
2012-03
影响因子：
6.7
通讯作者：
Chun, Jerold
中科院分区：
文献类型：
--
作者：
Ye, Xiaoqin;Diao, Honglu;Chun, Jerold
关键词：
确定环加氧酶（考克斯）衍生的前列腺素信号传导在缓解Lpar 3（-/-）雌性胚胎拥挤中的作用。实验小鼠模型。研究实验室。野生型、Lpar 3（+/−）和Lpar 3（−/−）小鼠。腹膜内（i. p.）向着床前妊娠第3.5天Lpar 3（−/−）雌性动物给予前列腺素E2（PGE 2）、cPGI（PGI 2的稳定类似物）和11-脱氧前列腺素F2α（11-脱氧PGF 2 α，血栓烷A2（TxA 2）受体（TP）激动剂）。通过蓝色染料反应检测着床部位，通过妊娠第4.5天着床部位沿着子宫角的分布确定胚胎间距;通过出生时的窝仔数测量妊娠结局。在妊娠第3.5天给予PGE 2 + cPGI Lpar 3（−/−）雌性动物恢复了按时着床，但不影响胚胎间隔或妊娠第4.5天检测到的着床部位数量; PGE 2 + cPGI给药增加了出生时的窝仔数。在妊娠第3.5天给予PGE 2 + cPGI + 11-脱氧PGF 2 α Lpar 3（−/−）雌性动物可挽救按时着床，部分分散通常在Lpar 3（−/−）雌性动物中观察到的群集着床部位，增加妊娠第4.5天检测到的着床部位数量，并增加出生时的窝仔数。TP激动剂11-脱氧PGF 2 α可以部分缓解Lpar 3（−/−）雌性的胚胎拥挤，胚胎拥挤可能导致Lpar 3（−/−）雌性的窝仔数减少。
To determine cyclooxygenase (COX)-derived prostanoid signaling in alleviating embryo crowding in the Lpar3(−/−) females. Experimental mouse model. Research laboratories. Wild type, Lpar3(+/−), and Lpar3(−/−) mice. Intraperitoneal (i.p.) administration of prostaglandin E2 (PGE2), cPGI (a stable analogue of PGI2), and 11-deoxy prostaglandin F2α (11-deoxy PGF2α, a thromboxane A2 (TxA2) receptor (TP) agonist) to preimplantation gestation day 3.5 Lpar3(−/−) females. Implantation sites were detected by blue dye reaction and embryo spacing was determined by the distribution of the implantation sites along the uterine horns on gestation day 4.5; pregnancy outcome was measured by litter size at birth. Administration of PGE2 + cPGI on gestation day 3.5 Lpar3(−/−) females restored on-time implantation but did not affect embryo spacing or the number of implantation sites detected on gestation day 4.5; PGE2 + cPGI treatment increased litter size at birth. Administration of PGE2 + cPGI + 11-deoxy PGF2α on gestation day 3.5 Lpar3(−/−) females rescued on-time implantation, partially dispersed the clustered implantation sites normally observed in the Lpar3(−/−) females, increased the number of implantation sites detected on gestation day 4.5, and increased litter size at birth. The TP agonist 11-deoxy PGF2α can partially alleviate embryo crowding in the Lpar3(−/−) females and embryo crowding likely contributes to reduced litter size in the Lpar3(−/−) females.
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影响因子：
10.9
作者：
Ye, Xiaoqin;Chun, Jerold
通讯作者：
Chun, Jerold
影响因子：
6.7
作者：
Diao, Honglu;Paria, Bibhash C.;Xiao, Shuo;Ye, Xiaoqin
通讯作者：
Ye, Xiaoqin
DOI：
10.1074/jbc.m110.197202
发表时间：
2011-02-11
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Chen Q;Zhang Y;Peng H;Lei L;Kuang H;Zhang L;Ning L;Cao Y;Duan E
通讯作者：
Duan E
影响因子：
3.6
作者：
YOSHINAGA, K;RICE, C;PILOT, RL
通讯作者：
PILOT, RL
DOI：
10.1530/jrf.0.0860039
发表时间：
1989-05-01
期刊：
JOURNAL OF REPRODUCTION AND FERTILITY
影响因子：
--
作者：
LEGRAND, C;BANUELOSNEVAREZ, A;MALTIER, JP
通讯作者：
MALTIER, JP