Maintenance of genome sequence integrity in long- and short-lived rodent species.
Maintenance of genome sequence integrity in long- and short-lived rodent species.
复制标题
长寿和短寿啮齿动物物种基因组序列完整性的维持。
DOI：
10.1126/sciadv.abj3284
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发表时间：
2021-10-29
期刊：
影响因子：
13.6
通讯作者：
Vijg J
中科院分区：
文献类型：
--
作者：
Zhang L;Dong X;Tian X;Lee M;Ablaeva J;Firsanov D;Lee SG;Maslov AY;Gladyshev VN;Seluanov A;Gorbunova V;Vijg J
Somatic mutation rates are inversely correlated with life span in mouse, guinea pig, blind mole-rat, naked mole-rat, and humans. DNA mutations in somatic cells have been implicated in the causation of aging, with longer-lived species having a higher capacity to maintain genome sequence integrity than shorter-lived species. In an attempt to directly test this hypothesis, we used single-cell whole-genome sequencing to analyze spontaneous and bleomycin-induced somatic mutations in lung fibroblasts of four rodent species with distinct maximum life spans, including mouse, guinea pig, blind mole-rat, and naked mole-rat, as well as humans. As predicted, the mutagen-induced mutation frequencies inversely correlated with species-specific maximum life span, with the greatest difference observed between the mouse and all other species. These results suggest that long-lived species are capable of processing DNA damage in a more accurate way than short-lived species.
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影响因子：
64.5
作者：
López-Otín C;Blasco MA;Partridge L;Serrano M;Kroemer G
通讯作者：
Kroemer G
影响因子：
48
作者：
Dong X;Zhang L;Milholland B;Lee M;Maslov AY;Wang T;Vijg J
通讯作者：
Vijg J
影响因子：
2.8
作者：
Hanawalt, PC
通讯作者：
Hanawalt, PC
DOI：
10.1126/science.aao4426
发表时间：
2018-02-02
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Lodato MA;Rodin RE;Bohrson CL;Coulter ME;Barton AR;Kwon M;Sherman MA;Vitzthum CM;Luquette LJ;Yandava CN;Yang P;Chittenden TW;Hatem NE;Ryu SC;Woodworth MB;Park PJ;Walsh CA
通讯作者：
Walsh CA
影响因子：
5.6
作者：
Lee, B. P.;Smith, M.;Harries, L. W.
通讯作者：
Harries, L. W.