Time from HIV seroconversion to death: a collaborative analysis of eight studies in six low and middle-income countries before highly active antiretroviral therapy.
Time from HIV seroconversion to death: a collaborative analysis of eight studies in six low and middle-income countries before highly active antiretroviral therapy.
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从HIV血清转化到死亡的时间：在高度活跃的抗逆转录病毒疗法之前对六个低收入和中等收入国家的八项研究进行了协作分析。
DOI：
10.1097/01.aids.0000299411.75269.e8
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发表时间：
2007-11
期刊：
影响因子：
--
通讯作者：
Zaba B
中科院分区：
文献类型：
--
作者：
Todd J;Glynn JR;Marston M;Lutalo T;Biraro S;Mwita W;Suriyanon V;Rangsin R;Nelson KE;Sonnenberg P;Fitzgerald D;Karita E;Zaba B
估计低收入和中等收入国家成年人感染艾滋病毒后的生存模式。对来自六个国家的八项不同研究的汇总数据进行分析。从8项研究（3项基于人群，2项职业和3项临床队列）中纳入HIV血清转换者，如果他们至少15岁，并且在最后一次HIV阴性和随后的HIV阳性检测之间不超过4年。定义了四个分层：东非队列;南非矿工队列;泰国队列;海地诊所队列。Kaplan-Meier函数用于估计生存模式，Weibull分布用于建模和扩展生存估计。分析研究了部位、年龄和性别对生存率的影响。在3823例合格的血清转换者中，在19671人年的随访中观察到1079例死亡。生存时间因年龄和研究中心而异。调整血清转换时的年龄25-29岁，南非矿工的中位生存期更长：11.6年[95%置信区间（CI）9.8-13.7]，东非队列：11.1年（95%CI 8.7-14.2）比海地：8.3年（95%CI 3.2-21.4）和泰国：7.5年（95%CI 5.4-10.4）。在调整血清转换时的年龄和部位后，男性和女性的生存率相似。在没有抗逆转录病毒治疗的情况下，非洲队列中艾滋病毒感染后的总体生存率与高收入国家的生存率相似，在血清转换时年龄较大的人进展更快的模式相似。在泰国，生存率似乎明显更差，其他不可测量的因素可能会影响进展。
To estimate survival patterns after HIV infection in adults in low and middle-income countries. An analysis of pooled data from eight different studies in six countries. HIV seroconverters were included from eight studies (three population-based, two occupational, and three clinic cohorts) if they were at least 15 years of age, and had no more than 4 years between the last HIV-negative and subsequent HIV-positive test. Four strata were defined: East African cohorts; South African miners cohort; Thai cohorts; Haitian clinic cohort. Kaplan–Meier functions were used to estimate survival patterns, and Weibull distributions were used to model and extend survival estimates. Analyses examined the effect of site, age, and sex on survival. From 3823 eligible seroconverters, 1079 deaths were observed in 19 671 person-years of follow-up. Survival times varied by age and by study site. Adjusting to age 25–29 years at seroconversion, the median survival was longer in South African miners: 11.6 years [95% confidence interval (CI) 9.8–13.7] and East African cohorts: 11.1 years (95% CI 8.7–14.2) than in Haiti: 8.3 years (95% CI 3.2–21.4) and Thailand: 7.5 years (95% CI 5.4–10.4). Survival was similar for men and women, after adjustment for age at seroconversion and site. Without antiretroviral therapy, overall survival after HIV infection in African cohorts was similar to survival in high-income countries, with a similar pattern of faster progression at older ages at seroconversion. Survival appears to be significantly worse in Thailand where other, unmeasured factors may affect progression.
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影响因子：
3.8
作者：
Morgan, D;Mahe, C;Whitworth, JAG
通讯作者：
Whitworth, JAG
影响因子：
3.8
作者：
MULDER, DW;NUNN, AJ;KENGEYAKAYONDO, JF
通讯作者：
KENGEYAKAYONDO, JF
影响因子：
158.5
作者：
Sterling, TR;Vlahov, D;Quinn, TC
通讯作者：
Quinn, TC
影响因子：
11.8
作者：
Lavreys, L;Baeten, JM;Overbaugh, J
通讯作者：
Overbaugh, J
影响因子：
168.9
作者：
Nduati, R;Richardson, BA;Kreiss, J
通讯作者：
Kreiss, J