Predicted effectiveness of vaccines and extended half-life monoclonal antibodies against RSV hospitalizations in children.
Predicted effectiveness of vaccines and extended half-life monoclonal antibodies against RSV hospitalizations in children.
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预测儿童RSV住院疫苗的有效性和延长半衰期的单克隆抗体。
DOI：
10.1038/s41541-022-00550-5
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发表时间：
2022-10-27
期刊：
影响因子：
9.2
通讯作者：
Pitzer, Virginia E.
中科院分区：
文献类型：
--
作者：
Zheng, Zhe;Weinberger, Daniel M.;Pitzer, Virginia E.
针对呼吸道合胞病毒（RSV）的几种疫苗和延长半衰期的单克隆抗体（mAb）已在临床试验中显示出前景。我们使用年龄结构传播模型来预测各种RSV预防策略的可能影响，包括母体免疫、减毒活疫苗和长效mAb。我们的研究结果表明，母体免疫和长效mAb可能在预防6个月以下婴儿的RSV住院治疗方面非常有效，避免了新生儿超过一半的RSV住院治疗。减毒活疫苗可以减少接种疫苗年龄组的RSV住院治疗，并且由于传播中断，预计在未接种疫苗年龄组中也会产生适度的影响。与全年疫苗接种相比，国家一级的季节性疫苗接种计划在效率方面至多提供较小的优势。我们的研究结果强调了即将到来的RSV预防策略可能带来的重大公共卫生影响。
Several vaccines and extended half-life monoclonal antibodies (mAbs) against respiratory syncytial virus (RSV) have shown promise in clinical trials. We used age-structured transmission models to predict the possible impact of various RSV prevention strategies including maternal immunization, live-attenuated vaccines, and long-lasting mAbs. Our results suggest that maternal immunization and long-lasting mAbs are likely to be highly effective in preventing RSV hospitalizations in infants under 6 months of age, averting more than half of RSV hospitalizations in neonates. Live-attenuated vaccines could reduce RSV hospitalizations in vaccinated age groups and are also predicted to have a modest effect in unvaccinated age groups because of disruptions to transmission. Compared to year-round vaccination, a seasonal vaccination program at the country level provides at most a minor advantage regarding efficiency. Our findings highlight the substantial public health impact that upcoming RSV prevention strategies may provide.
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DOI：
10.1093/cid/ciaa648
发表时间：
2021-12-06
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Buchwald AG;Graham BS;Traore A;Haidara FC;Chen M;Morabito K;Lin BC;Sow SO;Levine MM;Pasetti MF;Tapia MD
通讯作者：
Tapia MD
DOI：
10.15585/mmwr.mm7041a1
发表时间：
2021-10-15
期刊：
MMWR. Morbidity and mortality weekly report
影响因子：
--
作者：
Hill HA;Yankey D;Elam-Evans LD;Singleton JA;Sterrett N
通讯作者：
Sterrett N
DOI：
10.1016/s2468-2667(17)30103-2
发表时间：
2017-08
期刊：
The Lancet. Public health
影响因子：
--
作者：
Cromer D;van Hoek AJ;Newall AT;Pollard AJ;Jit M
通讯作者：
Jit M
影响因子：
5.1
作者：
HALL, CB;DOUGLAS, RG;GEIMAN, JM
通讯作者：
GEIMAN, JM
影响因子：
8
作者：
Fisher, RG;Gruber, WC;Wright, PF
通讯作者：
Wright, PF