Amyloid deposition is associated with impaired default network function in older persons without dementia.
Amyloid deposition is associated with impaired default network function in older persons without dementia.
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DOI：
10.1016/j.neuron.2009.07.003
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发表时间：
2009-07-30
期刊：
影响因子：
16.2
通讯作者：
Johnson, Keith A.
中科院分区：
文献类型：
--
作者：
Sperling, Reisa A.;LaViolette, Peter S.;O'Keefe, Kelly;O'Brien, Jacqueline;Rentz, Dorene M.;Pihlajamaki, Maija;Marshall, Gad;Hyman, Bradley T.;Selkoe, Dennis J.;Hedden, Trey;Buckner, Randy L.;Becker, J. Alex;Johnson, Keith A.
阿尔茨海默氏病（AD）与记忆功能相关的大脑区域分布式网络中的功能改变有关，最近关注的是统称为默认网络的皮质区域。默认网络的后部组件，包括楔前叶和后扣带回，特别容易受到淀粉样β蛋白早期沉积的影响，这是AD的标志性病理之一。在这项研究中，我们使用体内淀粉样蛋白成像来证明高水平的淀粉样蛋白沉积与无症状和轻度受损的老年人的异常默认网络功能磁共振成像（fMRI）活动相关，类似于AD患者报告的功能障碍模式。这些研究结果表明，淀粉样蛋白病理与支持记忆功能的脑区域的神经功能障碍有关，并为以下假设提供了支持：具有淀粉样蛋白病理证据的认知完整的老年人可能处于AD的早期阶段。
Alzheimer's disease (AD) has been associated with functional alterations in a distributed network of brain regions linked to memory function, with a recent focus on the cortical regions collectively known as the default network. Posterior components of the default network, including the precuneus and posterior cingulate, are particularly vulnerable to early deposition of amyloid β-protein, one of the hallmark pathologies of AD. In this study, we use in vivo amyloid imaging to demonstrate that high levels of amyloid deposition are associated with aberrant default network functional magnetic resonance imaging (fMRI) activity in asymptomatic and minimally impaired older individuals, similar to the pattern of dysfunction reported in AD patients. These findings suggest that amyloid pathology is linked to neural dysfunction in brain regions supporting memory function and provide support for the hypothesis that cognitively intact older individuals with evidence of amyloid pathology may be in early stages of AD.
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影响因子：
3.7
作者：
Dickerson, Bradford C.;Bakkour, Akram;Salat, David H.;Feczko, Eric;Pacheco, Jenni;Greve, Douglas N.;Grodstein, Fran;Wright, Christopher I.;Blacker, Deborah;Rosas, H. Diana;Sperling, Reisa A.;Atri, Alireza;Growdon, John H.;Hyman, Bradley T.;Morris, John C.;Fischl, Bruce;Buckner, Randy L.
通讯作者：
Buckner, Randy L.
影响因子：
5.7
作者：
Daselaar, SM;Prince, SE;Cabeza, R
通讯作者：
Cabeza, R
影响因子：
14.5
作者：
Daselaar, SM;Veltman, DJ;Jonker, C
通讯作者：
Jonker, C
DOI：
10.1073/pnas.0308627101
发表时间：
2004-03-30
影响因子：
11.1
作者：
Greicius, MD;Srivastava, G;Menon, V
通讯作者：
Menon, V
影响因子：
5.7
作者：
Fransson, Peter;Marrelec, Guillaume
通讯作者：
Marrelec, Guillaume