The genetics of obesity: from discovery to biology.
The genetics of obesity: from discovery to biology.
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DOI：
10.1038/s41576-021-00414-z
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发表时间：
2022-03
期刊：
影响因子：
--
通讯作者：
Yeo GSH
中科院分区：
文献类型：
--
作者：
Loos RJF;Yeo GSH
在过去的40年里，肥胖症的流行率增加了两倍，给人们的健康带来了巨大的负担。多基因(或常见)肥胖和罕见的、严重的、发病早的单基因肥胖通常被两极分化为不同的疾病。然而，对这两种肥胖症的基因发现研究表明，它们都有共同的遗传和生物学基础，这表明大脑在控制体重方面发挥了关键作用。随着样本量的增加和测序技术的进步，全基因组关联研究(GWAS)是最近一系列新发现背后的主要驱动力。然而，将新的组学技术和分析方法结合在一起的后GWAS跨学科合作，已经开始促进将遗传基因座转化为有意义的生物学和新的治疗途径。在这篇综述中，Loos和Yeo总结了我们目前对单基因和多基因肥胖的遗传基础的理解。他们强调了最近的研究揭示的共性，并讨论了对肥胖风险的治疗和预测的影响。
The prevalence of obesity has tripled over the past four decades, imposing an enormous burden on people’s health. Polygenic (or common) obesity and rare, severe, early-onset monogenic obesity are often polarized as distinct diseases. However, gene discovery studies for both forms of obesity show that they have shared genetic and biological underpinnings, pointing to a key role for the brain in the control of body weight. Genome-wide association studies (GWAS) with increasing sample sizes and advances in sequencing technology are the main drivers behind a recent flurry of new discoveries. However, it is the post-GWAS, cross-disciplinary collaborations, which combine new omics technologies and analytical approaches, that have started to facilitate translation of genetic loci into meaningful biology and new avenues for treatment. In this Review, Loos and Yeo summarize our current understanding of the genetic underpinnings of monogenic and polygenic obesity. They highlight the commonalities revealed by recent studies and discuss the implications for treatment and prediction of obesity risk.
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通讯作者：
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影响因子：
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通讯作者：
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