Coordinating Global Multi-Site Studies of Military-Relevant Traumatic Brain Injury: Opportunities, Challenges, and Harmonization Guidelines.
Coordinating Global Multi-Site Studies of Military-Relevant Traumatic Brain Injury: Opportunities, Challenges, and Harmonization Guidelines.
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DOI：
10.1007/s11682-020-00423-2
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发表时间：
2021-04
影响因子：
3.2
通讯作者：
Wilde EA
中科院分区：
文献类型：
--
作者：
Tate DF;Dennis EL;Adams JT;Adamson MM;Belanger HG;Bigler ED;Bouchard HC;Clark AL;Delano-Wood LM;Disner SG;Eapen BC;Franz CE;Geuze E;Goodrich-Hunsaker NJ;Han K;Hayes JP;Hinds SR 2nd;Hodges CB;Hovenden ES;Irimia A;Kenney K;Koerte IK;Kremen WS;Levin HS;Lindsey HM;Morey RA;Newsome MR;Ollinger J;Pugh MJ;Scheibel RS;Shenton ME;Sullivan DR;Taylor BA;Troyanskaya M;Velez C;Wade BS;Wang X;Ware AL;Zafonte R;Thompson PM;Wilde EA
创伤性脑损伤（TBI）在军人和平民中都较为常见，其后往往会出现一系列多样的临床、认知、行为、情绪及神经影像学变化。与许多具有特征性中枢神经异常区域（可作为疾病诊断依据）的神经系统疾病不同，严重的头部撞击可能导致脑部局灶性、多灶性、弥漫性损伤或多种损伤并存。这种表现的不一致性使得难以确立或验证有助于提高该患者群体诊断和预后准确性的生物学及影像学标志物。本文旨在阐述开展与军事相关的TBI研究时面临的挑战与机遇，并介绍通过元分析增强神经影像学遗传学（ENIGMA）军事脑损伤工作组。ENIGMA是一个全球性联盟，致力于通过数据共享与协作提高研究的可重复性和分析效能。在本文中，我们探讨了影响该患者群体数据汇总工作的挑战。此外，我们重点阐述了 “大数据” 方法如何有助于更好地理解这些变量在军人和退伍军人TBI的影像学及功能表型中可能发挥的作用，以及如何利用数据来研究诸如重返岗位、战斗相关损伤的远期影响以及自然衰老过程改变等重要的军事特定问题。
Traumatic brain injury (TBI) is common among military personnel and the civilian population and is often followed by a heterogeneous array of clinical, cognitive, behavioral, mood, and neuroimaging changes. Unlike many neurological disorders that have a characteristic abnormal central neurologic area(s) of abnormality pathognomonic to the disorder, a sufficient head impact may cause focal, multifocal, diffuse or combination of injury to the brain. This inconsistent presentation makes it difficult to establish or validate biological and imaging markers that could help improve diagnostic and prognostic accuracy in this patient population. The purpose of this manuscript is to describe both the challenges and opportunities when conducting military-relevant TBI research and introduce the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Military Brain Injury working group. ENIGMA is a worldwide consortium focused on improving replicability and analytical power through data sharing and collaboration. In this paper, we discuss challenges affecting efforts to aggregate data in this patient group. In addition, we highlight how “big data” approaches might be used to understand better the role that each of these variables might play in the imaging and functional phenotypes of TBI in Service member and Veteran populations, and how data may be used to examine important military specific issues such as return to duty, the late effects of combat-related injury, and alteration of the natural aging processes.
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影响因子：
6.8
作者：
Butler O;Adolf J;Gleich T;Willmund G;Zimmermann P;Lindenberger U;Gallinat J;Kühn S
通讯作者：
Kühn S
影响因子：
2.4
作者：
Bazarian, Jeffrey J.;Donnelly, Kerry;Zhong, Jianhui
通讯作者：
Zhong, Jianhui
影响因子：
2.6
作者：
Cooper, Douglas B.;Nelson, Lonnie;Bowles, Amy O.
通讯作者：
Bowles, Amy O.
影响因子：
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作者：
Bowman GL;Kaye JA;Quinn JF
通讯作者：
Quinn JF
影响因子：
1.2
作者：
Ben Barnes, J.;Presseau, Candice;Taylor, Daniel J.
通讯作者：
Taylor, Daniel J.