States of quinolinic acid excess in urine: A systematic review of human studies.
States of quinolinic acid excess in urine: A systematic review of human studies.
复制标题
尿中喹啉酸过量的状态：对人类研究的系统回顾。
DOI：
10.3389/fnut.2022.1070435
复制
发表时间：
2022
影响因子：
5
通讯作者：
Parikh, Samir M.
中科院分区：
文献类型：
--
作者：
Saade, Marie Christelle;Clark, Amanda J.;Parikh, Samir M.
关键词：
喹啉酸是源自膳食色氨酸代谢的中间化合物。据报道，其在患有多种疾病和病症的患者中积累。在这篇手稿中，我们介绍了评估尿喹啉酸对健康和疾病的研究的系统回顾结果。我们使用 PubMed、Cochrane 和 Scopus 数据库对 1949 年 12 月至 2022 年 1 月期间报告人类受试者尿喹啉酸数据的所有研究进行了文献综述。57 篇文章符合纳入标准。在大多数已报道的研究中，与对照组相比，患有不同疾病和病症的患者尿液中喹啉酸的浓度有所增加。该代谢物还被证明与某些疾病的严重程度相关，包括青少年特发性炎症性肌病、移植物抗宿主病、自闭症谱系障碍和前列腺癌。在危重患者中，尿液中喹啉酸升高预示着一系列不良后果，包括医院死亡率。喹啉酸与多种病症的病理生理学有关。它在尿液中的积聚似乎是急性生理应激和几种慢性疾病的一个特征。这些发现的确切意义仍在调查中，需要进一步的研究来揭示这种积累的后续影响。
Quinolinic acid is an intermediate compound derived from the metabolism of dietary tryptophan. Its accumulation has been reported in patients suffering a broad spectrum of diseases and conditions. In this manuscript, we present the results of a systematic review of research studies assessing urinary quinolinic acid in health and disease. We performed a literature review using PubMed, Cochrane, and Scopus databases of all studies reporting data on urinary quinolinic acid in human subjects from December 1949 to January 2022. Fifty-seven articles met the inclusion criteria. In most of the reported studies, compared to the control group, quinolinic acid was shown to be at increased concentration in urine of patients suffering from different diseases and conditions. This metabolite was also demonstrated to correlate with the severity of certain diseases including juvenile idiopathic inflammatory myopathies, graft vs. host disease, autism spectrum disorder, and prostate cancer. In critically ill patients, elevated quinolinic acid in urine predicted a spectrum of adverse outcomes including hospital mortality. Quinolinic acid has been implicated in the pathophysiology of multiple conditions. Its urinary accumulation appears to be a feature of acute physiological stress and several chronic diseases. The exact significance of these findings is still under investigation, and further studies are needed to reveal the subsequent implications of this accumulation.
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DOI：
10.1038/gim.2017.251
发表时间：
2018-10
期刊：
Genetics in medicine : official journal of the American College of Medical Genetics
影响因子：
--
作者：
Boczonadi V;King MS;Smith AC;Olahova M;Bansagi B;Roos A;Eyassu F;Borchers C;Ramesh V;Lochmüller H;Polvikoski T;Whittaker RG;Pyle A;Griffin H;Taylor RW;Chinnery PF;Robinson AJ;Kunji ERS;Horvath R
通讯作者：
Horvath R
影响因子：
4.2
作者：
BROWN, RR;YESS, N;HANKES, LV
通讯作者：
HANKES, LV
影响因子：
8
作者：
Bignon Y;Rinaldi A;Nadour Z;Poindessous V;Nemazanyy I;Lenoir O;Fohlen B;Weill-Raynal P;Hertig A;Karras A;Galichon P;Naesens M;Anglicheau D;Cippà PE;Pallet N
通讯作者：
Pallet N
影响因子：
4.1
作者：
Esturau-Escofet N;Rodríguez de San Miguel E;Vela-Amieva M;García-Aguilera ME;Hernández-Espino CC;Macias-Kauffer L;López-Candiani C;Naveja JJ;Ibarra-González I
通讯作者：
Ibarra-González I
影响因子：
6.2
作者：
Gevi F;Zolla L;Gabriele S;Persico AM
通讯作者：
Persico AM