A Longitudinal (1)H NMR-Based Metabolic Profile Analysis of Urine from Hospitalized Premature Newborns Receiving Enteral and Parenteral Nutrition.
A Longitudinal (1)H NMR-Based Metabolic Profile Analysis of Urine from Hospitalized Premature Newborns Receiving Enteral and Parenteral Nutrition.
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接受肠内和肠外营养的早产儿住院患者尿液的纵向（1）H NMR代谢谱分析。
DOI：
10.3390/metabo12030255
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发表时间：
2022-03-17
期刊：
影响因子：
4.1
通讯作者：
Ibarra-González I
中科院分区：
文献类型：
--
作者：
Esturau-Escofet N;Rodríguez de San Miguel E;Vela-Amieva M;García-Aguilera ME;Hernández-Espino CC;Macias-Kauffer L;López-Candiani C;Naveja JJ;Ibarra-González I
早产新生儿极易发病、并发症和死亡。早产是一个全球性的公共卫生问题，由于其社会经济负担。喂养早产儿是一个关键的医疗问题，因为他们的营养储备有限，很难建立肠内喂养，这导致生长不足，往往与不良的神经发育结果。肠外营养（PN）为早产儿提供营养，但其生化作用尚不完全清楚。为了研究PN治疗对早产儿的影响，对34例住院患者的107份尿液样本进行了非靶向代谢组学1H核磁共振（NMR）分析。使用多变量数据（主成分分析、PCA、正交偏最小二乘判别分析OPLS-DA、平行因子分析PARAFAC-2）和单变量分析来确定特定光谱数据与不同营养类型（NT）和胎龄的相关性。我们的研究结果揭示了与NT相关的代谢谱的变化，其中三羧酸循环和半乳糖代谢途径是受影响最大的途径。尽管葡萄糖相对尿液浓度较高，但低柠檬酸盐和琥珀酸盐水平似乎构成了接受PN的研究重症早产新生儿中发现的代谢特征，表明必须考虑能量障碍以进行更好的营养管理。
Preterm newborns are extremely vulnerable to morbidities, complications, and death. Preterm birth is a global public health problem due to its socioeconomic burden. Nurturing preterm newborns is a critical medical issue because they have limited nutrient stores and it is difficult to establish enteral feeding, which leads to inadequate growth frequently associated with poor neurodevelopmental outcomes. Parenteral nutrition (PN) provides nutrients to preterm newborns, but its biochemical effects are not completely known. To study the effect of PN treatment on preterm newborns, an untargeted metabolomic 1H nuclear magnetic resonance (NMR) assay was performed on 107 urine samples from 34 hospitalized patients. Multivariate data (Principal Component Analysis, PCA, Orthogonal partial least squares discriminant analysis OPLS-DA, parallel factor analysis PARAFAC-2) and univariate analyses were used to identify the association of specific spectral data with different nutritional types (NTs) and gestational ages. Our results revealed changes in the metabolic profile related to the NT, with the tricarboxylic acid cycle and galactose metabolic pathways being the most impacted pathways. Low citrate and succinate levels, despite higher glucose relative urinary concentrations, seem to constitute the metabolic profile found in the studied critically ill preterm newborns who received PN, indicating an energetic dysfunction that must be taken into account for better nutritional management.
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影响因子：
--
作者：
Tataranno ML;Perrone S;Longini M;Coviello C;Tassini M;Vivi A;Calderisi M;deVries LS;Groenendaal F;Buonocore G;Benders MJNL
通讯作者：
Benders MJNL
影响因子：
5
作者：
Marincola, Flaminia Cesare;Dessi, Angelica;Fanos, Vassilios
通讯作者：
Fanos, Vassilios
DOI：
10.1007/s00467-016-3439-9
发表时间：
2017-01
期刊：
Pediatric nephrology (Berlin, Germany)
影响因子：
--
作者：
Mercier K;McRitchie S;Pathmasiri W;Novokhatny A;Koralkar R;Askenazi D;Brophy PD;Sumner S
通讯作者：
Sumner S
影响因子：
3.1
作者：
Gracie, Sara;Pennell, Craig;Gravett, Michael
通讯作者：
Gravett, Michael
影响因子：
5.9
作者：
Moltu SJ;Sachse D;Blakstad EW;Strømmen K;Nakstad B;Almaas AN;Westerberg AC;Rønnestad A;Brække K;Veierød MB;Iversen PO;Rise F;Berg JP;Drevon CA
通讯作者：
Drevon CA