Association between dietary saturated fat with cardiovascular disease risk markers and body composition in healthy adults: findings from the cross-sectional BODYCON study.
Association between dietary saturated fat with cardiovascular disease risk markers and body composition in healthy adults: findings from the cross-sectional BODYCON study.
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DOI：
10.1186/s12986-022-00650-y
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发表时间：
2022-03-03
影响因子：
4.5
通讯作者：
Jackson KG
中科院分区：
文献类型：
--
作者：
Ozen E;Mihaylova R;Weech M;Kinsella S;Lovegrove JA;Jackson KG
高饱和脂肪酸(SFA)的饮食和更严重的腹型肥胖都与低密度脂蛋白胆固醇(LDL-C)浓度升高有关，低密度脂蛋白胆固醇(LDL-C)是一种独立的心血管疾病(CVD)风险标记。虽然减少SFA摄入量是预防心血管疾病的公共卫生策略，但体脂分布在SFA和低密度脂蛋白-C之间的关系中的作用尚不清楚。因此，我们的目标是调查膳食SFA和低密度脂蛋白浓度之间的关联是否与身体成分有关。在BodyCon(生理和生活方式因素对身体成分的影响)研究中，409名成年人[平均年龄42 ± 16岁，体重指数中位数为23.5(21.5-25.9)kg/m2]接受了双能X射线吸收法测量身体成分，使用4天称重食物日记评估习惯饮食摄入量，并使用三轴加速计评估体力活动水平。测量血压，并采集空腹血样以确定心脏代谢性疾病风险标记物。在进行多元回归分析之前，评估了身体成分、循环危险标记物和饮食常量营养素之间的相关性。在调整协变量后，使用ANCOVA来评估增加膳食SFA摄入量对结果指标的影响。腹部内脏脂肪质量与总胆固醇、低密度脂蛋白胆固醇、收缩压、舒张压和HOMA-IR呈中度正相关(rS = 0.2 5~0.44，p <； 0.0 1)。在多元回归分析中，SFA摄入量[总能量百分比(TE)]、腹部VAT质量、碳水化合物%TE和脂肪%TE可解释LDL-C变异的18.3%。按SFA%TE摄入量增加进行分层后，第四季度的空腹总胆固醇、低密度脂蛋白胆固醇和非高密度脂蛋白胆固醇均高于第二季度(p ≤ 0.03)。收缩压在第四季度高于第三季度(p = 0.01)。安卓的瘦身质量在第三季度也高于第一季度(p = 0.02)。其他人体测量学和心血管疾病风险标记物在四分位数组之间没有差异。尽管膳食SFA被发现可以解释9%的低密度脂蛋白-C的变异性，但根据SFA摄入量的四分位数对数据进行分层并没有揭示出与低密度脂蛋白浓度之间的剂量依赖关系。此外，在该队列中，这种关联似乎独立于腹型肥胖。临床试验登记：试验登记：ClinicalTrials.gov AS NCT02658539。2016年1月20日注册，https://clinicaltrials.gov/ct2/show/NCT02658539.网上版载有补充材料，可在10.1186/s12986-022-00650-y查阅。
Diets high in saturated fatty acids (SFAs) and greater abdominal obesity are both associated with raised low-density lipoprotein cholesterol (LDL-C) concentrations, an independent cardiovascular disease (CVD) risk marker. Although reducing SFA intake is a public health strategy for CVD prevention, the role of body fat distribution on the relationship between SFA and LDL-C is unclear. Therefore, our objective was to investigate whether the association between dietary SFAs and LDL-C concentrations is related to body composition. In the BODYCON (impact of physiological and lifestyle factors on body composition) study, 409 adults [mean age 42 ± 16 years and median BMI of 23.5 (21.5–25.9) kg/m2] underwent a measure of body composition by dual energy x-ray absorptiometry, assessment of habitual dietary intake using a 4-day weighed food diary and physical activity level using a tri-axial accelerometer. Blood pressure was measured, and a fasting blood sample was collected to determine cardiometabolic disease risk markers. Correlations between body composition, circulating risk markers and dietary macronutrients were assessed prior to multivariate regression analysis. The effect of increasing intakes of dietary SFA on outcome measures was assessed using ANCOVA after adjusting for covariates. Abdominal visceral adipose tissue (VAT) mass was moderately positively correlated with total cholesterol (TC), LDL-C, systolic blood pressure (SBP), diastolic blood pressure and HOMA-IR (rs = 0.25–0.44, p < 0.01). In multiple regression analysis, 18.3% of the variability in LDL-C was explained by SFA intake [% total energy (TE)], abdominal VAT mass, carbohydrate%TE and fat%TE intakes. When data were stratified according to increasing SFA%TE intakes, fasting TC, LDL-C and non-high-density lipoprotein-cholesterol were higher in Q4 compared with Q2 (p ≤ 0.03). SBP was higher in Q4 versus Q3 (p = 0.01). Android lean mass was also higher in Q3 versus Q1 (p = 0.02). Other anthropometric and CVD risk markers were not different across quartile groups. Although dietary SFA was found to explain 9% of the variability in LDL-C, stratification of data according to quartiles of SFA intake did not reveal a dose-dependent relationship with LDL-C concentration. Furthermore, this association appeared to be independent of abdominal obesity in this cohort. Clinical Trail registration: Trial registration: clinicaltrials.gov as NCT02658539. Registered 20 January 2016, https://clinicaltrials.gov/ct2/show/NCT02658539. The online version contains supplementary material available at 10.1186/s12986-022-00650-y.
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影响因子：
7.1
作者：
Bjermo, Helena;Iggman, David;Riserus, Ulf
通讯作者：
Riserus, Ulf
影响因子：
2
作者：
Aprahamian TR;Sam F
通讯作者：
Sam F
DOI：
10.1097/00005768-199805000-00021
发表时间：
1998-05-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Freedson, PS;Melanson, E;Sirard, J
通讯作者：
Sirard, J
DOI：
10.3390/healthcare5020029
发表时间：
2017-06-21
期刊：
Healthcare (Basel, Switzerland)
影响因子：
--
作者：
Briggs MA;Petersen KS;Kris-Etherton PM
通讯作者：
Kris-Etherton PM
影响因子：
5.8
作者：
Greenfield, JR;Samaras, K;Campbell, LV
通讯作者：
Campbell, LV