Nociceptive inputs into rostral ventrolateral medulla‐spinal vasomotor neurones in rats.
Nociceptive inputs into rostral ventrolateral medulla‐spinal vasomotor neurones in rats.
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大鼠头端腹外侧延髓脊髓血管运动神经元的伤害性输入。
DOI：
10.1113/jphysiol.1991.sp018573
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
K. Spyer
中科院分区：
文献类型：
--
作者：
M. Sun;K. Spyer
1. 在麻醉的大鼠中，记录了38个具有脊髓突出轴突的吻侧腹外侧髓质神经元。他们对机械、热和/或电刺激的反应以及伴随的动脉压变化进行了检查。2. 机械、热和电刺激的任何一个后爪的强度可以被认为是有害的产生持续上升的动脉压。RVL -脊髓突出的“血管运动”神经元被有害的机械和热（52摄氏度）刺激激发，其潜伏期比诱发的压力反应短。3. 经皮电刺激任何一条后肢的结果是兴奋的早期高峰（14个中的14个），抑制的早期低谷（14个中的12个），以及更晚的兴奋高峰（14个中的2个）。这种对任何一个肢体刺激的反应模式与哪个肢体被激活无关，但对侧后爪刺激在更短的潜伏期内引起兴奋。刺激尾部两个位置的反应潜伏期的差异表明，RVL -脊髓“血管舒缩”神经元的早期兴奋和抑制是通过在a δ范围内平均传导速度的外周纤维的激活而引起的。4. 当单脉冲刺激在脊髓外侧部分传递时，RVL -脊髓“血管舒缩”神经元的短潜伏期兴奋和抑制反应也被观察到。5. 双管碱（一种GABAA受体拮抗剂）的离子池应用阻断了这些神经元对后爪电刺激的诱发抑制，而不会减弱来自相同刺激的兴奋输入。6. 这些结果表明，RVL -脊髓“血管舒缩”神经元接受来自皮肤伤害性传入的输入。这表明，这些神经元至少部分地介导了与伤害感受器刺激相关的心血管反应。
1. In anaesthetized rats recordings were made from thirty‐eight neurones in the rostral ventrolateral medulla (RVL) with spinal‐projecting axons. Their responses to mechanical, thermal and/or electrical stimulation were examined as were the accompanying changes in arterial pressure. 2. Mechanical, thermal and electrical stimulation of either hindpaw at a strength that can be regarded as noxious produced a consistent rise in arterial pressure. RVL‐spinal‐projecting ‘vasomotor’ neurones were excited by the noxious mechanical and thermal (52 degrees C) stimulation at a latency that was shorter than that of the evoked pressor response. 3. Percutaneous electrical stimulation of either hindlimb extremity resulted in an early peak of excitation (fourteen out of fourteen), an early trough of inhibition (twelve out fourteen), and a later peak of excitation (two out of fourteen). This response pattern to stimulation of either limb was independent of which limb was activated, but contralateral hindpaw stimulation elicited excitation at a shorter latency. The differences in latency of responses to stimulating two locations along the tail suggested that the early excitation and inhibition of RVL‐spinal ‘vasomotor’ neurones were evoked by activation of peripheral fibres with a mean conduction velocity in the A delta range. 4. Short‐latency excitatory and inhibitory responses in RVL‐spinal ‘vasomotor’ neurones were observed also when single‐pulse stimuli were delivered within the lateral part of the spinal cord. 5. Ionophoretic application of bicuculline, a GABAA receptor antagonist, blocked the evoked inhibition of these neurones on electrical stimulation of the hindpaw without attenuating the excitatory input from the same stimulus. 6. These results indicate that RVL‐spinal ‘vasomotor’ neurones receive an input from cutaneous nociceptive afferents. This suggests that these neurones mediate, at least partly, the cardiovascular responses related to nociceptor stimulation.
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DOI：
10.1152/ajpregu.1987.252.4.r699
发表时间：
1987
期刊：
The American journal of physiology
影响因子：
--
作者：
Sun,MK;Guyenet,PG
通讯作者：
Guyenet,PG
影响因子：
--
作者：
HASELTON, JR;GUYENET, PG
通讯作者：
GUYENET, PG
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DOI：
10.1152/ajpregu.1985.249.6.r672
发表时间：
1985
期刊：
The American journal of physiology
影响因子：
--
作者：
Sun,MK;Guyenet,PG
通讯作者：
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DOI：
10.1152/ajpregu.1986.250.5.r910
发表时间：
1986
期刊：
The American journal of physiology
影响因子：
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作者：
Sun,MK;Guyenet,PG
通讯作者：
Guyenet,PG