Physical activity and asthma: a systematic review and meta-analysis.
Physical activity and asthma: a systematic review and meta-analysis.
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DOI：
10.1371/journal.pone.0050775
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Prins MH
中科院分区：
文献类型：
--
作者：
Eijkemans M;Mommers M;Draaisma JM;Thijs C;Prins MH
本综述旨在概述有关儿童、青少年和成人体力活动与哮喘之间关系的现有已发表证据。我们纳入了所有在病例对照、横断面或纵向（队列）研究中评估体力活动和哮喘的原始文章。排除了关于体能的研究、运动员研究、治疗或康复干预研究，如哮喘患者的体育训练或锻炼。根据Newcastle-Ottawa量表（NOS）评估纳入文献的方法学质量。进行了文献检索，直至2011年6月，检索到6，951篇来自PubMed的出版物和1，978篇来自EMBASE的出版物。总共有39项研究符合入选标准：5项纵向研究（受试者总数n = 85，117）以基线时的体力活动作为暴露，哮喘发病率作为结局。 纳入了34项横断面研究（n =661，222）。 纵向研究的汇总显示，体力活动水平较高的受试者哮喘发病率较低（比值比0.88（95%CI：0.77-1.01））。当将汇总限制在4项研究质量为中等至良好（定义为NOS≥5）的前瞻性研究时，汇总比值比仅略有变化（0.87（95% CI：0.77-0.99））。在横断面研究中，由于较大的临床变异性和异质性，无法进行进一步的统计分析。现有证据表明，体力活动可能是预防哮喘发展的一个保护因素。这种异质性表明，可能的相关影响仍然隐藏在关键年龄段、性别差异或极端身体活动水平（例如久坐）中。未来的纵向研究应解决这些问题。
This review aims to give an overview of available published evidence concerning the association between physical activity and asthma in children, adolescents and adults. We included all original articles in which both physical activity and asthma were assessed in case-control, cross-sectional or longitudinal (cohort) studies. Excluded were studies concerning physical fitness, studies in athletes, therapeutic or rehabilitation intervention studies such as physical training or exercise in asthma patients. Methodological quality of the included articles was assessed according to the Newcastle-Ottawa Scale (NOS). A literature search was performed until June 2011 and resulted in 6,951 publications derived from PubMed and 1,978 publications from EMBASE. In total, 39 studies met the inclusion criteria: 5 longitudinal studies (total number of subjects n = 85,117) with physical activity at baseline as exposure, and asthma incidence as outcome. Thirty-four cross-sectional studies (n = 661,222) were included. Pooling of the longitudinal studies showed that subjects with higher physical activity levels had lower incidence of asthma (odds ratio 0.88 (95% CI: 0.77–1.01)). When restricting pooling to the 4 prospective studies with moderate to good study quality (defined as NOS≥5) the pooled odds ratio only changed slightly (0.87 (95% CI: 0.77–0.99)). In the cross-sectional studies, due to large clinical variability and heterogeneity, further statistical analysis was not possible. The available evidence indicates that physical activity is a possible protective factor against asthma development. The heterogeneity suggests that possible relevant effects remain hidden in critical age periods, sex differences, or extremes of levels of physical activity (e.g. sedentary). Future longitudinal studies should address these issues.
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影响因子：
120.7
作者：
Flegal, Katherine M.;Carroll, Margaret D.;Curtin, Lester R.
通讯作者：
Curtin, Lester R.
影响因子：
4.3
作者：
Benet, Marta;Varraso, Raphaelle;Garcia-Aymerich, Judith
通讯作者：
Garcia-Aymerich, Judith
影响因子：
3.1
作者：
Firrincieli, V;Keller, A;Platts-Mills, T
通讯作者：
Platts-Mills, T
DOI：
10.1097/pep.0b013e318157da3d
发表时间：
2007-01-01
期刊：
Pediatric physical therapy : the official publication of the Section on Pediatrics of the American Physical Therapy Association
影响因子：
--
作者：
Gannotti, Mary;Veneri, Diana;Roberts, Dawn
通讯作者：
Roberts, Dawn
影响因子：
4.3
作者：
Huovinen, E;Kaprio, J;Koskenvuo, M
通讯作者：
Koskenvuo, M