Mice transgenic with SV40-late-promoter-driven Polyomavirus Middle T oncogene exclusively develop hemangiomas
Mice transgenic with SV40-late-promoter-driven Polyomavirus Middle T oncogene exclusively develop hemangiomas
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SV40晚期启动子驱动的多瘤病毒中T癌基因转基因小鼠只产生血管瘤
DOI：
10.1007/s11248-008-9232-1
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发表时间：
2009-06
影响因子：
3
通讯作者：
Wang, Zhugang
中科院分区：
文献类型：
--
作者：
Chen, Wantao;Xu, Qin;Zhang, Zhiyuan;Zheng, Jiawei;Wang, Zhugang
In order to develop a model system of infantile hemangioma, transgenic mice were developed carrying the Polyomavirus Middle T (PyMT) gene driven by the SV40 late promoter. From the 520 fertilized eggs surviving microinjection, there were 25 live births. Three of these showed the hemangioma phenotype and carried and expressed thePyMTgene; the remaining descendants were normal. The tumors showed abnormal vascular proliferation with cavernous hemangioma-like structures in the skin surface, tongue, ear mucosa and gastric mucosal tissue in the transgenic mice with hemangioma phenotype. Immunohistochemical staining for Ki-67 was negative, showing the tumors were hemangiomas rather than angiosarcomas. None of thePyMTtransgenic mice survived beyond 4 weeks. Previously reportedPyMTtransgenic mice under the control of various promoters induce many tumor types including hemangiomas.PyMTdriven by the SV40 late promoter is an improved model system because it only induces hemangiomas. However, it is limited by the post-natal lethality. Thus, conditional variants of this model system would be desirable.
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影响因子：
4.4
作者：
E. Giraudo;M. Arese;C. Toniatti;M. Strasly;L. Primo;A. Mantovani;G. Ciliberto;F. Bussolini
通讯作者：
E. Giraudo;M. Arese;C. Toniatti;M. Strasly;L. Primo;A. Mantovani;G. Ciliberto;F. Bussolini
影响因子：
11.2
作者：
Sandra Liekens;Erik Verbeken;Michel Vandeputte;E. Clercq;Johan Neyts
通讯作者：
Sandra Liekens;Erik Verbeken;Michel Vandeputte;E. Clercq;Johan Neyts
影响因子：
5.6
作者：
Terri A. Rothermel;B. Engelhardt;N. Sheibani
通讯作者：
Terri A. Rothermel;B. Engelhardt;N. Sheibani
影响因子：
3.7
作者：
DUBOIS, NA;KOLPACK, LC;BAUTCH, VL
通讯作者：
BAUTCH, VL
影响因子：
64.5
作者：
R.Lindsay Williams;S. Courtneidge;E. Wagner
通讯作者：
R.Lindsay Williams;S. Courtneidge;E. Wagner