Altered monoaminergic levels, spasticity, and balance disability following repetitive blast-induced traumatic brain injury in rats.
Altered monoaminergic levels, spasticity, and balance disability following repetitive blast-induced traumatic brain injury in rats.
复制标题
大鼠反复冲击波诱导的创伤性脑损伤后单胺能水平、痉挛状态和平衡障碍的改变。
DOI：
10.1016/j.brainres.2020.147060
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发表时间：
2020-11-15
期刊：
影响因子：
2.9
通讯作者：
中科院分区：
文献类型：
--
作者：
痉挛和平衡障碍是创伤性脑损伤（TBI）后的主要并发症。虽然单胺输入为运动系统提供了关键的适应性神经调节，但关于重复性爆炸性脑损伤（bTBI）后与运动功能相关的大脑区域的单胺水平的数据尚不清楚。本研究的目的是确定轻度重复性脑外伤是否会导致痉挛/平衡障碍，以及这些障碍是否与运动系统相关脑区去甲肾上腺素、多巴胺和血清素水平的改变有关。在第1、4、7天，用爆炸超压波诱导雄性大鼠重复性脑损伤。脑外伤后，进行生理/行为测试，并收集中枢运动系统组织（即运动皮质、蓝斑、前庭核和腰椎脊髓），用高效液相色谱法电化学检测去甲肾上腺素、多巴胺和血清素。结果显示，去甲肾上腺素在蓝斑区显著升高，前庭核区显著降低，多巴胺在前庭核区显著降低。另一方面，运动皮质和腰椎脊髓的血清素显著增加。由于这些单胺在调节神经元兴奋性方面发挥重要作用，这些结果表明，轻度、重复性脑外伤引起的中枢运动系统单胺输入失调可能导致痉挛和平衡障碍。这是第一个报道急性轻度重复性脑外伤后中枢运动系统中多种单胺水平改变的研究。
Spasticity and balance disability are major complications following traumatic brain injury (TBI). Although monoaminergic inputs provide critical adaptive neuromodulations to the motor system, data are not available regarding the levels of monoamines in the brain regions related to motor functions following repetitive blast TBI (bTBI). The objective of this study was to determine if mild, repetitive bTBI results in spasticity/balance deficits and if these are correlated with altered levels of norepinephrine, dopamine, and serotonin in the brain regions related to the motor system. Repetitive bTBI was induced by a blast overpressure wave in male rats on days 1, 4, and 7. Following bTBI, physiological/behavioral tests were conducted and tissues in the central motor system (i.e., motor cortex, locus coeruleus, vestibular nuclei, and lumbar spinal cord) were collected for electrochemical detection of norepinephrine, dopamine, and serotonin by high-performance liquid chromatography. The results showed that norepinephrine was significantly increased in the locus coeruleus and decreased in the vestibular nuclei, while dopamine was significantly decreased in the vestibular nuclei. On the other hand, serotonin was significantly increased in the motor cortex and the lumbar spinal cord. Because these monoamines play important roles in regulating the excitability of neurons, these results suggest that mild, repetitive bTBI-induced dysregulation of monoaminergic inputs in the central motor system could contribute to spasticity and balance disability. This is the first study to report altered levels of multiple monoamines in the central motor system following acute mild, repetitive bTBI.
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DOI：
10.1016/j.apmr.2013.12.019
发表时间：
2014-06-01
影响因子：
4.3
作者：
Borrini, Leo;Bensmail, Djamel;Jourdan, Claire
通讯作者：
Jourdan, Claire
影响因子：
4.2
作者：
Bose, Prodip;Hou, Jiamei;Thompson, Floyd J.
通讯作者：
Thompson, Floyd J.
影响因子：
14.5
作者：
Dentel, Christel;Palamiuc, Lavinia;Dupuis, Luc
通讯作者：
Dupuis, Luc
影响因子：
5.3
作者：
Brown, Andrew R.;Teskey, G. Campbell
通讯作者：
Teskey, G. Campbell
影响因子：
3.3
作者：
Barresi, M.;Grasso, C.;Volsi, G. Li
通讯作者：
Volsi, G. Li