Compressive Properties and Hydraulic Permeability of Human Meniscus: Relationships With Tissue Structure and Composition.
Compressive Properties and Hydraulic Permeability of Human Meniscus: Relationships With Tissue Structure and Composition.
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DOI：
10.3389/fbioe.2020.622552
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发表时间：
2020
影响因子：
5.7
通讯作者：
Travascio F
中科院分区：
文献类型：
--
作者：
Morejon A;Norberg CD;De Rosa M;Best TM;Jackson AR;Travascio F
半月板在维持膝关节功能和保护关节免受包括骨性关节炎在内的继发性病理损害方面至关重要。研究表明，半月板可以吸收高达75%的膝关节总负荷。半月板组织在压缩过程中的力学行为可以通过量化力学参数来预测，其中包括骨料模数(H)和泊松模数(ν)，以及流体传输参数：水力渗透率(K)。这些参数对于开发组织的计算模型以及模拟天然组织的组织工程支架的设计和开发至关重要。因此，这项研究的目的是表征人半月板的力学和流体运输特性，并将它们与组织成分联系起来。标本从组织的轴向和周向解剖平面制备。应力松弛试验得到了H，而有限元模拟得到了ν和K的曲线，并研究了模数与水分和糖胺聚糖(GAG)含量的关系。平均H为0.11±0.078 Mpa，ν为0.32±0.057，K为2.9±2.27×10−15m4N−1s−1。H、ν和K参数在不同受压方向和不同受压程度之间无统计学差异。组织含水量为77±3.3%，GAG含量为8.79±1.1%。H与水分含量呈弱负相关(R2~34%)，K与GAG含量呈正相关(R2~53%)。总而言之，尽管在不同的样品取向和压缩程度上没有发现传输和压缩特性的显著差异，但数据趋势表明H和K的大小与Gag含量之间存在潜在的关系。
The meniscus is crucial in maintaining knee function and protecting the joint from secondary pathologies, including osteoarthritis. The meniscus has been shown to absorb up to 75% of the total load on the knee joint. Mechanical behavior of meniscal tissue in compression can be predicted by quantifying the mechanical parameters including; aggregate modulus (H) and Poisson modulus (ν), and the fluid transport parameter: hydraulic permeability (K). These parameters are crucial to develop a computational model of the tissue and for the design and development of tissue engineered scaffolds mimicking the native tissue. Hence, the objective of this study was to characterize the mechanical and fluid transport properties of human meniscus and relate them to the tissue composition. Specimens were prepared from the axial and the circumferential anatomical planes of the tissue. Stress relaxation tests yielded the H, while finite element modeling was used to curve fit for ν and K. Correlations of moduli with water and glycosaminoglycans (GAGs) content were investigated. On average H was found to be 0.11 ± 0.078 MPa, ν was 0.32 ± 0.057, and K was 2.9 ± 2.27 × 10−15 m4N−1s−1. The parameters H, ν, and K were not found to be statistically different across compression orientation or compression level. Water content of the tissue was 77 ± 3.3% while GAG content was 8.79 ± 1.1%. Interestingly, a weak negative correlation was found between H and water content (R2 ~ 34%) and a positive correlation between K and GAG content (R2 ~ 53%). In conclusion, while no significant differences in transport and compressive properties can be found across sample orientation and compression levels, data trends suggest potential relationships between magnitudes of H and K, and GAG content.
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影响因子：
7
作者：
Burton-Wurster, N;Liu, W;Roughley, PJ
通讯作者：
Roughley, PJ
DOI：
10.1002/jbm.820290706
发表时间：
1995-07-01
期刊：
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH
影响因子：
--
作者：
JOSHI, MD;SUH, JK;WOO, SLY
通讯作者：
WOO, SLY
影响因子：
6.6
作者：
BOWEN, RM
通讯作者：
BOWEN, RM
影响因子：
2.7
作者：
Murphy, Louise;Helmick, Charles G.
通讯作者：
Helmick, Charles G.
DOI：
10.1016/j.jmbbm.2013.05.027
发表时间：
2013-10-01
影响因子：
3.9
作者：
Seitz, Andreas Martin;Galbusera, Fabio;Duerselen, Lutz
通讯作者：
Duerselen, Lutz