MicroRNA-204 plays a role as a tumor suppressor in Newcastle disease virus-induced oncolysis in lung cancer A549 cells.
MicroRNA-204 plays a role as a tumor suppressor in Newcastle disease virus-induced oncolysis in lung cancer A549 cells.
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MicroRNA-204在新城疫病毒诱导的肺癌A549细胞溶瘤中发挥抑瘤作用。
DOI：
10.3892/ol.2021.12743
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发表时间：
2021-06
期刊：
影响因子：
2.9
通讯作者：
Fan XH
中科院分区：
文献类型：
--
作者：
Liang Y;Tian WY;Huang JJ;Gao LX;Fan XH
肿瘤的发生和发展与各种microrna （miRNAs/miRs）密切相关。我们以前已经证实新城疫病毒（NDV） 7793株在肺癌中诱导肿瘤溶解。然而，NDV对肺癌的溶瘤作用机制仍有待进一步研究。本研究通过体外溶瘤诱导，评估了miR-204在ndv诱导的肺癌A549细胞溶瘤中的作用。miR-204在ndv处理的A549细胞中显著上调。在A549细胞中，miR-204的过表达或抑制与ndv诱导的肿瘤溶解显著相关。凋亡通路的主要调控因子Caspase-3和Bax受miR-204调控，在ndv介导的肿瘤溶解中发现Caspase-3相关的凋亡与miR-204之间存在关联。这些数据表明，miR-204作为肿瘤抑制因子在ndv诱导的肺癌细胞溶瘤中发挥作用。本研究证明了使用miRs提高溶瘤NDV效力的策略的潜力，并强调了miR-204在NDV诱导的肺癌细胞溶瘤中的抑癌作用。
Tumor development and progression are closely associated with various microRNAs (miRNAs/miRs). We have previously shown that Newcastle disease virus (NDV) strain 7793 induces oncolysis in lung cancer. However, how NDV exerts its oncolytic effect on lung cancer remains to be investigated. The present study assessed the role of miR-204 in the NDV-induced oncolysis of lung cancer A549 cells by oncolysis induction in vitro. miR-204 was significantly upregulated in NDV-treated A549 cells. Overexpression or inhibition of miR-204 was significantly associated with NDV-induced oncolysis in A549 cells. Caspase-3 and Bax, major regulators of the apoptosis pathway, were regulated by miR-204, and the association between caspase-3-related apoptosis and miR-204 was identified in NDV-mediated oncolysis. These data demonstrated that miR-204 as a tumor suppressor played a role in NDV-induced oncolysis in lung cancer cells. The present study demonstrates the potential of strategies using miRs to improve oncolytic NDV potency, and highlights miR-204 as a tumor suppressor in NDV-induced oncolysis of lung cancer cells.
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影响因子：
4.7
作者：
Al-Shammari AM;Salman MI;Saihood YD;Yaseen NY;Raed K;Shaker HK;Ahmed A;Khalid A;Duiach A
通讯作者：
Duiach A
影响因子：
158.5
作者：
Sandler, Alan;Gray, Robert;Johnson, David H.
通讯作者：
Johnson, David H.
DOI：
10.1007/978-3-030-12457-1_24
发表时间：
2020-01-01
期刊：
CALCIUM SIGNALING, 2ND EDITION
影响因子：
--
作者：
Santoni, Giorgio;Morelli, Maria Beatrice;Amantini, Consuelo
通讯作者：
Amantini, Consuelo
影响因子：
2.7
作者：
Bian, Jianchun;Wang, Kai;Meng, Songshu
通讯作者：
Meng, Songshu
影响因子：
4.2
作者：
Ghrici M;El Zowalaty M;Omar AR;Ideris A
通讯作者：
Ideris A