Withdrawal from long-term methamphetamine self-administration 'normalizes' neurometabolites in rhesus monkeys: a (1) H MR spectroscopy study.
Withdrawal from long-term methamphetamine self-administration 'normalizes' neurometabolites in rhesus monkeys: a (1) H MR spectroscopy study.
复制标题
DOI：
10.1111/adb.12078
复制
发表时间：
2015-01
影响因子：
3.4
通讯作者：
Yang Y
中科院分区：
文献类型：
--
作者：
Yang S;Belcher AM;Chefer S;Vaupel DB;Schindler CW;Stein EA;Yang Y
1H magnetic resonance spectroscopy has demonstrated alterations in several neurometabolites in methamphetamine (METH)-dependent individuals in brain regions implicated in addiction. Yet it is unclear whether these neurochemicals return to homeostatic levels after an individual abstains from drug use, a difficult question to address due to high recidivism and poor study retention in human subjects. We thus utilized a nonhuman primate model of addiction to explore the effects of long-term drug exposure and withdrawal on brain neurochemistry. Ten rhesus macaque monkeys on an active METH self-administration protocol (average use 4.6±0.8 years, average daily intake between 0.4-1.2 mg/kg) and 10 age- and sex-matched drug-naïve controls (CONT) served as subjects. Concentrations of several neurochemicals were evaluated at several time points following withdrawal from drug availability (10 monkeys at 1 week and 1 and 3 months, and 6 monkeys at 6 and 12 months; CONT examined at one time point). At one week following METH withdrawal, we found increases in myo-inositol in anterior cingulate cortex in the METH group relative to CONT. These alterations showed a linear pattern of decreased levels (‘normalization’) by one year of abstinence. We also found decreases in glutamine and Glx (composed mainly of glutamate and glutamine) in the caudate-putamen of the same animals at early withdrawal that showed a similar linear pattern of increasing concentration by one year. These results demonstrate that despite protracted, long-term use, neurochemical changes seen following long term drug administration do not persist following prolonged abstinence, suggesting therapeutic effects of long-term withdrawal from drug use.
登录
查看更多内容
DOI：
10.1017/s1461145705005699
发表时间：
2006-04-01
影响因子：
4.8
作者：
Kim, SJ;Lyoo, IK;Renshaw, PF
通讯作者：
Renshaw, PF
影响因子：
2.9
作者：
NASH, JF;YAMAMOTO, BK
通讯作者：
YAMAMOTO, BK
影响因子：
14
作者：
Griffith, H. Randall;den Hollander, Jan A.;Okonkwo, Ozioma C.;O'Brien, Timothy;Watts, Ray L.;Marson, Daniel C.
通讯作者：
Marson, Daniel C.
影响因子：
--
作者：
Cotter, D;Mackay, D;Everall, I
通讯作者：
Everall, I
影响因子：
25
作者：
Baker, DA;McFarland, K;Kalivas, PW
通讯作者：
Kalivas, PW