Effects of remifemin treatment on bone integrity and remodeling in rats with ovariectomy-induced osteoporosis.
Effects of remifemin treatment on bone integrity and remodeling in rats with ovariectomy-induced osteoporosis.
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Remifemin 治疗对卵巢切除所致骨质疏松大鼠骨完整性和重塑的影响
DOI：
10.1371/journal.pone.0082815
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Bai W
中科院分区：
文献类型：
--
作者：
Cui G;Leng H;Wang K;Wang J;Zhu S;Jia J;Chen X;Zhang W;Qin L;Bai W
本研究旨在评价瑞米芬（山楂异丙醇提取物）对绝经后骨质疏松症的影响。120只雌性Sprague-Dawley大鼠随机分为四组：假手术联合载药、载药联合卵巢切除术、戊酸雌二醇联合卵巢切除术、雷米明联合卵巢切除术。术后2周开始每日口服载药、戊酸雌二醇或瑞米芬，持续4、8或12周。每个时间步，每组处死10只大鼠，测定骨矿物质密度、骨小梁结构及股骨、腰椎生物力学参数。术后12周评估骨转换指标。两种药物均可防止卵巢切除术后股骨远端骨密度损失，并保留腰椎和股骨远端骨小梁结构。这两种药物都能保护被试区域的骨硬度，并减少去卵巢大鼠的骨重吸收。如果治疗时间适当延长，瑞米明对骨质流失的预防作用可与戊酸雌二醇相媲美。总之，瑞米芬在预防绝经后骨质疏松方面可能显示出与戊酸雌二醇相当的效果。
This study aims to evaluate the effects of Remifemin (isopropanolic extract of Cimicifuga Racemosa) on postmenopausal osteoporosis. 120 female Sprague-Dawley rats were randomly assigned to four groups: sham surgery with vehicle, ovariectomy with vehicle, ovariectomy with estradiol valerate, or ovariectomy with Remifemin. Daily oral administrations of the vehicle, estradiol valerate, or Remifemin began 2 weeks after surgery and lasted to 4, 8, or 12 weeks. Ten rats in each group were sacrificed at each timestep with assessment of bone mineral density, trabecular bone structure, and biomechanical parameters of the femur and lumbar vertebra. Bone turnover markers were evaluated 12 weeks after surgery. Both drugs prevented bone density loss in the distal end of the femur and preserved the trabecular bone structure in both the lumbar vertebra and distal end of the femur following ovariectomy. Both drugs protected bone stiffness at the tested regions and reduced bone reabsorption in ovariectomized rats. The preventive effects of Remifemin against bone-loss can rival those of estradiol valerate if treatment duration is adequately extended. In conclusion, Remifemin may demonstrate equivalent effects to estradiol valerate in terms of preventing postmenopausal osteoporosis.
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DOI：
10.1308/003588410x12699663903395
发表时间：
2010-09-01
影响因子：
1.4
作者：
Baqain, Zaid H.;Sawair, Faleh A.;Abbadi, Abdalla A.
通讯作者：
Abbadi, Abdalla A.
影响因子：
4.1
作者：
Devareddy, Latha;Khalil, Dania A.;Arjmandi, Bahram H.
通讯作者：
Arjmandi, Bahram H.
影响因子：
1.2
作者：
Nadaoka, Isao;Yasue, Masaaki;Kitagawa, Yasushi
通讯作者：
Kitagawa, Yasushi
影响因子：
6.2
作者：
Bhattacharyya, Sudeepa;Siegel, Eric R.;Suva, Larry J.
通讯作者：
Suva, Larry J.
影响因子：
8.2
作者：
Ma, Bo;Zhang, Qi;Ying, Han-jie
通讯作者：
Ying, Han-jie