Effects of green tea polyphenol (-)-epigallocatechin-3-gallate on newly developed high-fat/Western-style diet-induced obesity and metabolic syndrome in mice.
Effects of green tea polyphenol (-)-epigallocatechin-3-gallate on newly developed high-fat/Western-style diet-induced obesity and metabolic syndrome in mice.
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DOI：
10.1021/jf2029016
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发表时间：
2011-11-09
影响因子：
6.1
通讯作者：
Yang CS
中科院分区：
文献类型：
--
作者：
Chen YK;Cheung C;Reuhl KR;Liu AB;Lee MJ;Lu YP;Yang CS
本研究旨在探讨表没食子儿茶素没食子酸酯（EGCG）对一种新发现的高脂/西式饮食诱导的肥胖和代谢综合征症状的影响。雄性C57 BL/6 J小鼠喂食高脂肪/西式（HFW; 60%能量为脂肪，较低水平的钙、维生素D3、叶酸、酒石酸氢胆碱和纤维）或HFW与EGCG（HFWE; HFW与0.32%EGCG）饮食17周。作为比较，还包括另外两组喂食低脂肪（LF; 10%能量作为脂肪）和高脂肪（HF; 60%能量作为脂肪）的小鼠。HFW组体重增加和代谢综合征症状较HF组严重。与HFW组相比，EGCG治疗显著降低了与粪便脂质增加相关的体重增加，并降低了血糖和丙氨酸氨基转移酶（ALT）水平。脂肪肝的发病率，肝损伤和肝脏甘油三酯水平也降低了EGCG治疗。此外，EGCG治疗减弱了胰岛素抵抗和血浆胆固醇、单核细胞趋化蛋白-1（MCP-1）、C-反应蛋白（CRP）、白细胞介素-6（IL-6）和粒细胞集落刺激因子（G-CSF）的水平。我们的研究结果表明，HFW饮食比HF饮食产生更严重的代谢综合征症状，并且EGCG治疗可以减轻这些症状和体脂积累。表没食子儿茶素没食子酸酯的有益作用与减少脂质吸收和降低炎性细胞因子水平有关。
The aim of this study was to investigate the effects of (-)-epigallocatechin-3-gallate (EGCG) on a newly developed high-fat/Western-style diet-induced obesity and symptoms of metabolic syndrome. Male C57BL/6J mice were fed a high fat/Western-style (HFW; 60% energy as fat and lower levels of calcium, vitamin D3, folic acid, choline bitartrate, and fiber) or HFW with EGCG (HFWE; HFW with 0.32% EGCG) diet for 17 wk. As a comparison, two other groups of mice fed a low-fat (LF; 10% energy as fat) and high-fat (HF; 60% energy as fat) were also included. HFW group developed more body weight gain and severe symptoms of metabolic syndrome than the HF group. EGCG treatment significantly reduced body weight gain associated with increased fecal lipids, and decreased blood glucose and alanine aminotransferase (ALT) levels compared to the HFW group. Fatty liver incidence, liver damage and liver triglyceride levels were also decreased by EGCG treatment. Moreover, EGCG treatment attenuated insulin resistance and levels of plasma cholesterol, monocyte chemoattractant protein-1 (MCP-1), C-reactive protein (CRP), interlukin-6 (IL-6), and granulocyte colony-stimulating factor (G-CSF). Our results demonstrate that the HFW diet produces more severe symptoms of metabolic syndrome than the HF diet and EGCG treatment can alleviate these symptoms and body fat accumulation. The beneficial effects of EGCG are associated with decreased lipid absorption and reduced levels of inflammatory cytokines.
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DOI：
10.1093/jn/138.9.1677
发表时间：
2008-09
期刊：
The Journal of nutrition
影响因子：
--
作者：
Bose M;Lambert JD;Ju J;Reuhl KR;Shapses SA;Yang CS
通讯作者：
Yang CS
影响因子：
2.7
作者：
Koyama, Y;Abe, K;Isemura, M
通讯作者：
Isemura, M
影响因子：
7.7
作者：
Morino, Katsutaro;Petersen, Kitt Falk;Shulman, Gerald I.
通讯作者：
Shulman, Gerald I.
影响因子：
4.9
作者：
Aronson, D;Bartha, P;Levy, Y
通讯作者：
Levy, Y
影响因子：
4.2
作者：
Erdelyi, Ildiko;Levenkova, Natasha;Holt, Peter R.
通讯作者：
Holt, Peter R.