The Effect of Co-infection of Food-Borne Pathogenic Bacteria on the Progression of Campylobacter jejuni Infection in Mice.
The Effect of Co-infection of Food-Borne Pathogenic Bacteria on the Progression of Campylobacter jejuni Infection in Mice.
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DOI：
10.3389/fmicb.2018.01977
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发表时间：
2018
影响因子：
5.2
通讯作者：
Chen W
中科院分区：
文献类型：
--
作者：
Wang G;He Y;Jin X;Zhou Y;Chen X;Zhao J;Zhang H;Chen W
弯曲杆菌是一种常见的引起人类胃肠炎的食源性病原体。含有弯曲杆菌的食品也可能被其他病原体污染，然而，这种多重污染是否会导致更严重的感染仍不清楚。在这项研究中，小鼠灌胃空肠弯曲杆菌和其他食源性致病菌，以模拟多重感染。结果表明，C. C.空肠和鼠伤寒沙门氏菌感染，随后的弯曲杆菌病也得到加强，其特征是体重减轻，血便加重，结肠炎性变化更明显。此外，感染C.空肠也促进了肠侵袭性大肠杆菌的共感染，但随着时间的推移不受影响。与S.鼠伤寒沙门氏菌和肠侵袭性E. coli，单核细胞增生李斯特菌对C.空肠感染，甚至阻碍其进展。此外，肠道微生态也受到C.空肠弯曲菌与其他病原菌的感染，未分类肠杆菌科细菌相对丰度增加，丁酸水平降低，肠道微生物数种属的丰度发生变化，提示某些食源性致病菌可能影响空肠弯曲菌的发展。通过影响肠道微生物群的组成和由此产生的SCFA水平的变化，可以在小鼠中观察到空肠感染。总的来说，我们的研究结果表明，弯曲杆菌与其他病原菌的共同感染可以影响C。空肠弯曲菌感染小鼠的实验结果表明，该菌对人类健康的影响可能与弯曲菌的病原学有关。
Campylobacter is a well-known food-borne pathogen that causes human gastroenteritis. Food products that contain Campylobacter may also be contaminated by other pathogens, however, whether this multiple contamination leads to more severe infection remains unclear. In this study, mice were gavaged with Campylobacter jejuni and other food-borne pathogenic bacteria to mimic a multiple infection. It was demonstrated that the C. jejuni load was elevated when the mice were co-infected with C. jejuni and Salmonella typhimurium, and the campylobacteriosis that followed was also enhanced, with features of decreased body weight, heavier bloody stools and more pronounced inflammatory changes to the colon. In addition, infection with C. jejuni was also promoted by co-infection with entero-invasive Escherichia coli but unaffected over time. In contrast to S. typhimurium and entero-invasive E. coli, co-infection by Listeria monocytogenes showed little effect on C. jejuni infection and even hindered its progress. In addition, the intestinal microecology was also affected by co-infection of C. jejuni with other pathogens, with an increased relative abundance of unclassified Enterobacteriaceae, decreased levels of butyric acid and changes in the abundance of several genera of gut microbe, which suggests that some food-borne pathogenic bacteria might affect the progression of C. jejuni infection in mice by influencing the composition of the gut microbiota and the resulting changes in SCFA levels. Collectively, our findings suggest that co-infection of Campylobacter with other pathogenic bacteria can impact on the progression of infection by C. jejuni in mice, which may also have implication for the etiology of Campylobacter on human health.
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影响因子：
5.2
作者：
Atterby C;Mourkas E;Méric G;Pascoe B;Wang H;Waldenström J;Sheppard SK;Olsen B;Järhult JD;Ellström P
通讯作者：
Ellström P
影响因子：
3.7
作者：
Bereswill S;Fischer A;Plickert R;Haag LM;Otto B;Kühl AA;Dasti JI;Zautner AE;Muñoz M;Loddenkemper C;Gross U;Göbel UB;Heimesaat MM
通讯作者：
Heimesaat MM
影响因子：
3.7
作者：
Corridoni D;Pastorelli L;Mattioli B;Locovei S;Ishikawa D;Arseneau KO;Chieppa M;Cominelli F;Pizarro TT
通讯作者：
Pizarro TT
影响因子：
1.3
作者：
Dubey, JP;Speer, CA;Blixt, JA
通讯作者：
Blixt, JA
影响因子：
7.1
作者：
Clarke, Julie M.;Topping, David L.;Cobiac, Lynne
通讯作者：
Cobiac, Lynne