'Liking' and 'wanting' food rewards: brain substrates and roles in eating disorders.

'Liking' and 'wanting' food rewards: brain substrates and roles in eating disorders.
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DOI:
10.1016/j.physbeh.2009.02.044
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发表时间:
2009-07-14
影响因子:
2.9
通讯作者:
Berridge, Kent C.
Berridge, Kent C.
中科院分区:
医学3区
文献类型:
--
作者:
Berridge, Kent C.

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什么大脑奖励系统调节对食物奖励的动机“想要”和享乐“喜欢”?这些系统在饮食失调中发挥什么作用?本文调查了有关享乐“喜欢”的大脑机制的最新发现,例如伏隔核和腹侧苍白球中存在立方毫米的享乐热点,用于阿片类药物放大感官愉悦。它还认为大脑“想要”或刺激显着系统对食欲很重要,例如中脑边缘多巴胺系统和超出享乐热点的阿片类动机回路。最后,它考虑了“想要”和“喜欢”可能与饮食失调相关的一些潜在方式。
What brain reward systems mediate motivational ‘wanting’ and hedonic ‘liking’ for food rewards? And what roles do those systems play in eating disorders? This article surveys recent findings regarding brain mechanisms of hedonic ‘liking’, such as the existence of cubic-millimeter hedonic hotspots in nucleus accumbens and ventral pallidum for opioid amplification of sensory pleasure. It also considers brain ‘wanting’ or incentive salience systems important to appetite, such as mesolimbic dopamine systems and opioid motivation circuits that extend beyond the hedonic hotspots. Finally, it considers some potential ways in which ‘wanting’ and ‘liking’ might relate to eating disorders.
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