Variant brain-derived neurotrophic factor Val66Met endophenotypes: implications for posttraumatic stress disorder.
Variant brain-derived neurotrophic factor Val66Met endophenotypes: implications for posttraumatic stress disorder.
复制标题
DOI：
10.1111/j.1749-6632.2010.05722.x
复制
发表时间：
2010-10
影响因子：
5.2
通讯作者：
Lee FS
中科院分区：
文献类型：
--
作者：
Frielingsdorf H;Bath KG;Soliman F;Difede J;Casey BJ;Lee FS
最近，在编码脑源性神经营养因子(BDNF)的基因中发现了一种常见的单核苷酸多态性(SNP)。BDNFMet变异体已被证明减少了神经元依赖活动的BDNF分泌，并导致特定形式的学习障碍和对应激的敏感性改变。含有BDNFMet的小鼠模型也被认为与焦虑样行为增加有关。在一项翻译研究中，比较了携带BDNFMet等位基因的小鼠和人类消除后天恐惧记忆的能力。两者都表现出对后天恐惧反应的较慢抑制。在人类身上，这种行为的神经关联通过功能磁共振得到了验证。由于焦虑和恐惧的消退是创伤后应激障碍(PTSD)症状和治疗方法的核心，我们认为BDNF基因和神经成像可能是有用的生物标记物，为更个性化的治疗方向提供指导。本文的目的是综述关于BDNF Val66Met SNP的现有知识，重点是焦虑和恐惧相关的内表型及其对创伤后应激障碍的潜在影响。
Recently, a common single nucleotide polymorphism (SNP) has been identified in the gene encoding brain-derived neurotrophic factor (BDNF). The variant BDNFMet has been shown to have decreased activity-dependent BDNF secretion from neurons and to lead to impairments in specific forms of learning and altered susceptibility to stress. A mouse model containing BDNFMet has also been linked to increased anxiety-like behavior. In a translational study, mice and human carriers of the BDNFMet allele were compared in their ability to extinguish a learned fear memory. Both showed slower suppression of the learned fear response. In humans, the neural correlates of this behavior were validated using fMRI. As anxiety and fear extinction lie at the core of symptoms and therapeutic approaches to posttraumatic stress disorder (PTSD), we propose that BDNF genotype and neuroimaging may be useful as biomarkers to provide guidance for more customized therapeutic directions. The aim of this paper is to review the available knowledge on the BDNF Val66Met SNP, with emphasis on anxiety- and fear-related endophenotypes and its potential implications for PTSD.
登录
查看更多内容
影响因子：
--
作者：
Hofmann, SG;Meuret, AE;Otto, MW
通讯作者：
Otto, MW
影响因子：
5.3
作者：
Chen, ZY;Ieraci, A;Lee, FS
通讯作者：
Lee, FS
影响因子：
5.3
作者：
Hariri, AR;Goldberg, TE;Weinberger, DR
通讯作者：
Weinberger, DR
影响因子：
3.2
作者：
Frustaci, Alessandra;Pozzi, Gino;Boccia, Stefania
通讯作者：
Boccia, Stefania
影响因子：
4.8
作者：
Brunet, Alain;Orr, Scott P.;Pitman, Roger K.
通讯作者：
Pitman, Roger K.