Hepatic R2* is more strongly associated with proton density fat fraction than histologic liver iron scores in patients with nonalcoholic fatty liver disease.
Hepatic R2* is more strongly associated with proton density fat fraction than histologic liver iron scores in patients with nonalcoholic fatty liver disease.
复制标题
DOI：
10.1002/jmri.26312
复制
发表时间：
2019-05
期刊：
影响因子：
--
通讯作者：
NASH Clinical Research Network (NASH CRN)
中科院分区：
文献类型：
--
作者：
Bashir MR;Wolfson T;Gamst AC;Fowler KJ;Ohliger M;Shah SN;Alazraki A;Trout AT;Behling C;Allende DS;Loomba R;Sanyal A;Schwimmer J;Lavine JE;Shen W;Tonascia J;Van Natta ML;Mamidipalli A;Hooker J;Kowdley KV;Middleton MS;Sirlin CB;NASH Clinical Research Network (NASH CRN)
肝脏R2* 值被广泛用作肝脏铁的指标，但可能受到肝脏脂肪变性和其他协变量的混淆。识别非酒精性脂肪性肝病（NAFLD）患者肝脏R2* 值的最有影响力的协变量。前瞻性采集数据的回顾性分析，来自NAFLD/NASH治疗试验1.5T和3 T中招募的204名受试者的基线数据;化学位移编码多回波梯度回波肝脏质子密度脂肪分数与R2* 之间的相关性;评估肝脏R2* Pearson和斯皮尔曼相关性的人口统计学、代谢、实验室、MRI衍生和组织学协变量;单变量分析;梯度增强机器多变量机器学习方法肝脏PDFF是1.5T和1.5T下R2* 的最强相关协变量（r=0.652，p<0.0001）和在3 T（r=0.586，p<0.0001）。在GBM分析中，肝脏PDFF是对肝脏R2* 影响最大的协变量，1.5 T和3 T下的相对影响（RI）分别为61.3%和47.5%;影响较小的协变量在1.5 T和3 T下的RI分别高达11.5%和16.7%。非肝细胞铁仅在3 T下与R2* 弱相关（RI 6.7%），而肝细胞铁在任一场强下均与R2* 无关。在1.5T和3 T下，肝脏PDFF是R2* 的最有影响力的协变量;仅在3 T下，非肝细胞铁沉积与肝脏R2* 弱相关。
Liver R2* value is widely used as a measure of liver iron but may be confounded by the presence of hepatic steatosis and other covariates. To identify the most influential covariates for liver R2* values in patients with non-alcoholic fatty liver disease (NAFLD) Retrospective analysis of prospectively acquired data Baseline data from 204 subjects enrolled in NAFLD/NASH treatment trials 1.5T and 3T; Chemical-shift encoded multi-echo gradient echo Correlation between liver proton density fat fraction and R2*; assessment for demographic, metabolic, laboratory, MRI-derived, and histological covariates of liver R2* Pearson’s and Spearman’s correlations; univariate analysis; Gradient Boosting Machines multivariable machine learning method Hepatic PDFF was the most strongly correlated covariate for R2* at both 1.5T (r=0.652, p<0.0001) and at 3T (r=0.586, p<0.0001). In the GBM analysis, hepatic PDFF was the most influential covariate for hepatic R2*, with relative influences (RIs) of 61.3% at 1.5T and 47.5% at 3T; less influential covariates had RIs of up to 11.5% at 1.5T and 16.7% at 3T. Non-hepatocellular iron was weakly associated with R2* at 3T only (RI 6.7%), and hepatocellular iron was not associated with R2* at either field strength. Hepatic PDFF is the most influential covariate for R2* at both 1.5T and 3T; non-hepatocellular iron deposition is weakly associated with liver R2* at 3T only.
登录
查看更多内容
影响因子：
5.5
作者：
Labranche, Roxanne;Gilbert, Guillaume;Tang, An
通讯作者：
Tang, An
影响因子：
4.4
作者：
Mamidipalli, Adrija;Hamilton, Gavin;Sirlin, Claude B.
通讯作者：
Sirlin, Claude B.
影响因子：
3.3
作者：
Zhong, Xiaodong;Nickel, Marcel D.;Bashir, Mustafa R.
通讯作者：
Bashir, Mustafa R.
影响因子：
29.4
作者：
Schwimmer, Jeffrey B.;Lavine, Joel E.;Doo, Edward
通讯作者：
Doo, Edward
影响因子：
3.1
作者：
Roth, Christopher G.;Halegoua-De Marzio, Dina;Guglielmo, Flavius F.
通讯作者：
Guglielmo, Flavius F.