Biodegradable nanoparticles are excellent vehicle for site directed in-vivo delivery of drugs and vaccines.
Biodegradable nanoparticles are excellent vehicle for site directed in-vivo delivery of drugs and vaccines.
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DOI：
10.1186/1477-3155-9-55
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发表时间：
2011-11-28
影响因子：
10.2
通讯作者：
Singh DK
中科院分区：
文献类型：
--
作者：
Mahapatro A;Singh DK
可生物降解纳米颗粒（NPs）因其作为疫苗、基因、药物和其他生物分子在体内特定部位递送的可行载体的能力而越来越受到关注。它们为许多药物、疫苗和生物分子提供了增强的生物相容性、优越的药物/疫苗封装和方便的释放配置文件，可用于医学领域的各种应用。本文综述了生物可降解纳米颗粒的制备方法、影响最佳药物包封的不同因素、影响药物释放率的因素、纳米颗粒的各种表面修饰以增强体内循环、分布和多模态功能，以及这些颗粒在肿瘤靶向、口服给药和中枢神经系统的具体应用。
Biodegradable nanoparticles (NPs) are gaining increased attention for their ability to serve as a viable carrier for site specific delivery of vaccines, genes, drugs and other biomolecules in the body. They offer enhanced biocompatibility, superior drug/vaccine encapsulation, and convenient release profiles for a number of drugs, vaccines and biomolecules to be used in a variety of applications in the field of medicine. In this manuscript, the methods of preparation of biodegradable NPs, different factors affecting optimal drug encapsulation, factors affecting drug release rates, various surface modifications of nanoparticles to enhance in-vivo circulation, distribution and multimodal functionalities along with the specific applications such as tumor targeting, oral delivery, and delivery of these particles to the central nervous system have been reviewed.
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影响因子：
10.8
作者：
Aslani, P;Kennedy, RA
通讯作者：
Kennedy, RA
影响因子：
10.8
作者：
JENKINS, PG;HOWARD, KA;OHAGAN, DT
通讯作者：
OHAGAN, DT
影响因子：
14
作者：
Gref, R;Couvreur, P;Mysiakine, E
通讯作者：
Mysiakine, E
影响因子：
2.4
作者：
Chen, Y.;Dalwadi, G.;Benson, H. A. E.
通讯作者：
Benson, H. A. E.
影响因子：
3.7
作者：
Calvo, P;RemunanLopez, C;Alonso, MJ
通讯作者：
Alonso, MJ