Role of oxytocin in the ventral tegmental area in social reinforcement.
Role of oxytocin in the ventral tegmental area in social reinforcement.
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DOI：
10.1016/j.psyneuen.2018.05.028
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发表时间：
2018-09
影响因子：
3.7
通讯作者：
Albers HE
中科院分区：
文献类型：
--
作者：
Borland JM;Grantham KN;Aiani LM;Frantz KJ;Albers HE
社会互动的奖励属性在社会关系的发展和维持中起着关键作用，社会奖励的缺陷与各种精神疾病有关。在本研究中，我们使用了一种新的操作性社会偏好（OSP）的任务，调查社会互动的高或低的奖励值的条件下，高或低的行为努力在雄性叙利亚仓鼠的强化属性。此外，我们调查的作用，催产素（OT）的中脑边缘奖励系统的一个关键结构，腹侧被盖区（VTA），在介导的社会互动的强化性能。将成年雄性仓鼠置于三室装置中，并通过推动单向入口垂直摆动门进入含有不受限制的同种或非社会室的社会室。增加社会互动的持续时间（奖励值）降低了进入社会互动室的频率，而减少社会互动的持续时间反而增加了进入的频率。此外，越来越多的行为努力所需的访问社会互动的条目的频率下降，特别是在社会互动的持续时间只有5秒的条件下。OT注入腹侧被盖区降低了进入社会交往室的频率，其方式与持续时间增加时观察到的方式相似，而在腹侧被盖区注射OT受体拮抗剂增加了寻求社会交往的频率。综上所述，这些数据支持这样的假设，即腹侧被盖区中OT受体的激活对于社会互动的强化特性至关重要。此外，社会互动可能会表现出持续时间和成本依赖性的行为强化效果类似于观察到的食物和药物滥用。
The rewarding properties of social interactions play a critical role in the development and maintenance of social relationships, and deficits in social reward are associated with various psychiatric disorders. In the present study, we used a novel Operant Social Preference (OSP) task to investigate the reinforcing properties of social interactions under conditions of high or low reward value, and high or low behavioral effort in male Syrian hamsters. Further, we investigated the role of oxytocin (OT) in a key structure of the mesolimbic reward system, the ventral tegmental area (VTA), in mediating the reinforcing properties of social interaction. Adult male hamsters were placed in a three-chambered apparatus, and allowed access to either a social chamber containing an unrestrained conspecific or a non-social chamber, by pushing through a one-way entry, vertical-swing door. Increasing the duration of social interaction (reward value) decreased the frequency of entering the social interaction chambers, whereas decreasing the duration of social interaction conversely increased the frequency of entries. Moreover, increasing behavioral effort required to access social interaction decreased the frequency of entries, especially under conditions when the duration of social interaction was only 5 s. OT injected into the VTA decreased the frequency of entering social interaction chambers in a manner similar to that observed when duration was increased, whereas injection of an OT receptor antagonist in the VTA increased the frequency of seeking social interaction. Taken together, these data support the hypothesis that activation of OT receptors in the VTA are critical for the reinforcing properties of social interactions. Furthermore, social interactions may exhibit duration and cost dependent reinforcing effects on behavior similar to those observed with food and drugs of abuse.
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