A novel operant task to assess social reward and motivation in rodents.
A novel operant task to assess social reward and motivation in rodents.
复制标题
一项新的运营任务，以评估啮齿动物的社会奖励和动力。
DOI：
10.1016/j.jneumeth.2017.06.003
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发表时间：
2017-08-01
影响因子：
3
通讯作者：
Albers HE
中科院分区：
文献类型：
--
作者：
Borland JM;Frantz KJ;Aiani LM;Grantham KN;Song Z;Albers HE
社会奖赏在有益的社会关系的发展中起着关键作用，控制社会奖赏的机制障碍与许多精神疾病的病因有关。我们提出了一种新的操作性社会偏好任务，以量化社会奖励啮齿动物使用的装置与三个室分开的单向垂直摆动门。实验动物被放置在较大的腔室中，而两个较小的腔室保持空的或包含刺激动物或其他潜在的奖励刺激。在门上增加重量可以改变奖励所需的努力。仓鼠（Mesocricetus auratus）进入含有刺激仓鼠的腔室的频率明显高于空腔室。当社会互动的强化效果相比，食物奖励的累进成本要求下，社会互动和向日葵籽的强化效果是相似的。逐渐增加门的重量会减少进入的次数，但会增加试图打开门所花费的时间。社会互动的奖励属性的量化几乎完全使用条件位置偏好（CPP）范式。尽管CPP是可靠的，但它包含了记忆成分，因为它依赖于地点与社会互动的关联，而这里介绍的操作性任务则没有。这个任务允许详细和直接的评估社会和非社会奖励，可能作为有效的行为的奖励在这个操作性条件反射模型，它可以用来研究调节动机的神经机制。
Social reward plays a critical role in the development of beneficial social relationships, and disorders of the mechanisms controlling social reward are involved in the etiology of many psychiatric diseases. We present a novel operant social preference task to quantify social reward in rodents using an apparatus with three chambers separated by one-way vertical-swing doors. The experimental animal is placed in the larger chamber while the two smaller chambers either remain empty or contain a stimulus animal or other potential reward stimulus. Adding weights to the door can alter effort required for rewards. Hamsters (Mesocricetus auratus) entered the chamber containing a stimulus hamster significantly more frequently than an empty chamber. When the reinforcing effects of social interactions were compared to food reward under progressive cost requirements, the reinforcing effects of social interaction and sunflower seeds were similar. Progressively increasing the door weight decreased number of entries, but increased time spent attempting to open the doors. The quantification of the rewarding properties of social interactions has almost exclusively used the conditioned place preference (CPP) paradigm. Although robust and reliable, CPP includes a memory component, because it relies on the association of place with the social interaction while the operant task presented here does not. This task allows for detailed and direct assessment of social and non-social rewards that may serve as effective behavioral reinforcers in this operant conditioning model, and it can be used to investigate the neural mechanisms regulating motivation.
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影响因子：
4.9
作者：
Dichter GS;Damiano CA;Allen JA
通讯作者：
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