In vivo relationships between lumbar facet joint and intervertebral disc composition and diurnal deformation.
In vivo relationships between lumbar facet joint and intervertebral disc composition and diurnal deformation.
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DOI：
10.1016/j.clinbiomech.2021.105425
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发表时间：
2021-08
期刊：
影响因子：
--
通讯作者：
Martin JT
中科院分区：
文献类型：
--
作者：
Oldweiler AB;Martin JT
脊柱运动由“三关节复合体”、两个小关节和每个脊柱节段的一个椎间盘促进。椎间盘和小关节都受到与年龄相关的自然退化，虽然这些过程可能是联系在一起的，但尚不清楚如何联系。由于椎间盘的不稳定可能是小关节炎的基础，我们评估了椎间盘和小关节机械耦合的假设。我们招募了年轻的无症状志愿者（n=10;年龄：平均25岁，范围21-30岁; BMI：平均23.1，范围19.1-29.0 kg/m2），并应用磁共振成像（MRI）和三维（3D）建模来测量小关节面和椎间盘组成（MRI T1 rho弛豫时间）和腰椎小关节和椎间盘功能（小关节间隙宽度、椎间盘高度的昼夜变化）。我们发现，小关节间隙宽度与小关节T1 rho弛豫时间（液体含量）呈正相关，与椎间盘T1 rho呈负相关，退变椎间盘附近的小关节明显较厚，T1 rho明显较高。此外，楔角的昼夜变化与小关节间隙宽度的昼夜变化呈正相关，而椎间盘退变、椎间盘高度的昼夜变化和小关节T1 ρ则无相关性。这些数据表明，椎间盘和小关节健康之间的相互依存关系，但不是椎间盘和小关节的机械功能。此外，小关节软骨成分和体内功能之间的弱关系表明，其他因素，如脊柱弯曲，决定在体内脊柱力学。有必要在有症状或老年人群中进行进一步研究以证实这些发现。
Spinal motion is facilitated by a “three joint complex”, two facet joints and one intervertebral disc at each spinal level. Both the intervertebral discs and facet joints are subject to natural age-related degeneration, and while these processes may be linked it is not clear how. As instability in the disc could underlie facet arthritis, we evaluated the hypothesis that the discs and facet joints are mechanically coupled. We recruited young, asymptomatic volunteers (n=10; age: mean 25, range 21–30 years; BMI: mean 23.1, range 19.1–29.0 kg/m2) and applied magnetic resonance imaging (MRI) and three-dimensional (3D) modeling to measure facet and disc composition (MRI T1rho relaxation time) and facet and disc function (diurnal changes in facet space width, disc height) in the lumbar spine. We found that facet space width was positively associated with facet T1rho relaxation time (fluid content) and negatively associated with disc T1rho, and that facets adjacent to degenerated discs were significantly thicker and had significantly higher T1rho. Furthermore, the diurnal change in wedge angle was positively associated the diurnal change in facet space width, while disc degeneration, the diurnal change in disc height, and facet T1rho were not. These data demonstrate an interdependence between disc and facet health, but not between disc and facet mechanical function. Furthermore, the weak relationship between facet cartilage composition and in vivo function suggests that other factors, like spinal curvature, determine in vivo spine mechanics. Future work in symptomatic or aged populations are warranted to confirm these findings.
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DOI：
10.1002/jor.22355
发表时间：
2013-08
期刊：
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
影响因子：
--
作者：
Martin JT;Gorth DJ;Beattie EE;Harfe BD;Smith LJ;Elliott DM
通讯作者：
Elliott DM
影响因子：
4.5
作者：
Deyo, Richard A.;Dworkin, Samuel F.;Weiner, Debra K.
通讯作者：
Weiner, Debra K.
影响因子：
3
作者：
Jaumard, Nicolas V.;Udupa, Jayaram K.;Winkelstein, Beth A.
通讯作者：
Winkelstein, Beth A.
影响因子：
2.4
作者：
Martin, John T.;Oldweiler, Alexander B.;DeFrate, Louis E.
通讯作者：
DeFrate, Louis E.
影响因子：
2.8
作者：
Jamaludin, Amir;Lootus, Meelis;McCall, Iain
通讯作者：
McCall, Iain