Evolutionary conservation of the antimicrobial function of mucus: a first defence against infection.
Evolutionary conservation of the antimicrobial function of mucus: a first defence against infection.
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DOI：
10.1038/s41522-018-0057-2
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发表时间：
2018
影响因子：
9.2
通讯作者：
Burgess JG
中科院分区：
文献类型：
--
作者：
Bakshani CR;Morales-Garcia AL;Althaus M;Wilcox MD;Pearson JP;Bythell JC;Burgess JG
粘液层通常在生物体的上皮细胞与其外部环境之间提供独特的多功能水凝胶界面。粘液具有特殊的特性，包括弹性、可变的流变性和通过重新退火进行自我修复的能力，因此是捕获和固定病原体并作为微生物感染屏障的理想介质。产生功能性表面粘膜的能力是重要的进化步骤，它首先在包括珊瑚在内的刺胞动物和栉水母动物中进化。这使得非共生微生物被排除，并且随后在高等后生动物中看到粘液衬里的消化腔的发育。糖蛋白粘蛋白的基本结构在进化上也是保守的。尽管了解细菌和粘液层之间的生化相互作用对于开发新的抗菌策略的目标很重要，但人们对它们的了解仍然相对较少。这篇综述总结了粘液的理化特性和进化重要性，这使得粘液在预防细菌感染方面如此成功。此外，还探索了细菌对抗粘液层的策略。
Mucus layers often provide a unique and multi-functional hydrogel interface between the epithelial cells of organisms and their external environment. Mucus has exceptional properties including elasticity, changeable rheology and an ability to self-repair by re-annealing, and is therefore an ideal medium for trapping and immobilising pathogens and serving as a barrier to microbial infection. The ability to produce a functional surface mucosa was an important evolutionary step, which evolved first in the Cnidaria, which includes corals, and the Ctenophora. This allowed the exclusion of non-commensal microbes and the subsequent development of the mucus-lined digestive cavity seen in higher metazoans. The fundamental architecture of the constituent glycoprotein mucins is also evolutionarily conserved. Although an understanding of the biochemical interactions between bacteria and the mucus layer are important to the goal of developing new antimicrobial strategies, they remain relatively poorly understood. This review summarises the physicochemical properties and evolutionary importance of mucus, which make it so successful in the prevention of bacterial infection. In addition, the strategies developed by bacteria to counteract the mucus layer are also explored.
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DOI：
10.1099/00221287-146-7-1717
发表时间：
2000-07-01
期刊：
MICROBIOLOGY-UK
影响因子：
--
作者：
Chance, DL;Mawhinney, TP
通讯作者：
Mawhinney, TP
DOI：
10.1126/science.1223012
发表时间：
2012-08-24
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Button B;Cai LH;Ehre C;Kesimer M;Hill DB;Sheehan JK;Boucher RC;Rubinstein M
通讯作者：
Rubinstein M
影响因子：
4.6
作者：
Biggerstaff, Andrew;Smith, David J.;Bell, James J.
通讯作者：
Bell, James J.
影响因子：
9.2
作者：
Caldara, Marina;Friedlander, Ronn S.;Kavanaugh, Nicole L.;Aizenberg, Joanna;Foster, Kevin R.;Ribbeck, Katharina
通讯作者：
Ribbeck, Katharina
DOI：
10.1152/ajpgi.2001.280.5.g922
发表时间：
2001-05-01
影响因子：
4.5
作者：
Atuma, C;Strugala, V;Holm, L
通讯作者：
Holm, L