Physical Exercise-Induced Myokines and Muscle-Adipose Tissue Crosstalk: A Review of Current Knowledge and the Implications for Health and Metabolic Diseases.
Physical Exercise-Induced Myokines and Muscle-Adipose Tissue Crosstalk: A Review of Current Knowledge and the Implications for Health and Metabolic Diseases.
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DOI：
10.3389/fphys.2018.01307
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发表时间：
2018
影响因子：
4
通讯作者：
Batista ML Jr
中科院分区：
文献类型：
--
作者：
Leal LG;Lopes MA;Batista ML Jr
体育锻炼对代谢性疾病具有有益的影响，并且经常推荐定期锻炼和药物治疗的组合治疗方案用于其临床管理。然而，运动产生这些有益效果的机制尚未完全了解。肌因子是一组骨骼肌源性多肽，在这一过程中可能发挥重要作用。肌细胞因子由肌纤维在收缩时产生、表达和释放，并发挥局部和多效性作用。在体育锻炼过程中释放的肌因子如IL-6，IL-10和IL-1 ra介导其健康益处。就像运动似乎可以促进肌因子反应一样，身体不活动似乎会削弱它，这可能是解释久坐行为和许多慢性疾病之间联系的一种机制。肌因子通过释放能够与其他组织（主要是脂肪组织（AT））相互作用的体液因子，帮助配置免疫-代谢因子界面和体育锻炼的健康促进作用。AT本身由于缺乏体力活动而分泌促炎细胞因子（脂肪因子），并且众所周知，AT炎症可导致代谢疾病的发展，例如2型糖尿病（T2 DM）和动脉粥样硬化。另一方面，AT的布朗宁表型被认为是体育锻炼改善超重/肥胖个体身体组成的机制之一。虽然，许多细胞因子参与了SkM和AT之间的串扰，但就这些效应而言，IL-6、IL-15、鸢尾素和肌肉生长抑制素似乎在AT和SkM之间的这种“对话”中具有决定性作用。这篇综述文章提出了汇集最新的“最先进的”知识关于肌细胞因子和肌肉脂肪组织串扰。此外，它旨在特别关注肌因子直接介导的AT的免疫代谢变化。
Physical exercise has beneficial effects on metabolic diseases, and a combined therapeutic regimen of regular exercise and pharmaceutical treatment is often recommended for their clinical management. However, the mechanisms by which exercise produces these beneficial effects are not fully understood. Myokines, a group of skeletal muscle (SkM) derived peptides may play an important part in this process. Myokines are produced, expressed and released by muscle fibers under contraction and exert both local and pleiotropic effects. Myokines such as IL-6, IL-10, and IL-1ra released during physical exercise mediate its health benefits. Just as exercise seems to promote the myokine response, physical inactivity seems to impair it, and could be a mechanism to explain the association between sedentary behavior and many chronic diseases. Myokines help configure the immune-metabolic factor interface and the health promoting effects of physical exercise through the release of humoral factors capable of interacting with other tissues, mainly adipose tissue (AT). AT itself secretes proinflammatory cytokines (adipokines) as a result of physical inactivity and it is well recognized that AT inflammation can lead to the development of metabolic diseases, such as type 2 diabetes mellitus (T2DM) and atherosclerosis. On the other hand, the browning phenotype of AT has been suggested to be one of the mechanisms through which physical exercise improves body composition in overweight/obese individuals. Although, many cytokines are involved in the crosstalk between SkM and AT, in respect of these effects, it is IL-6, IL-15, irisin, and myostatin which seem to have the decisive role in this “conversation” between AT and SkM. This review article proposes to bring together the latest “state of the art” knowledge regarding Myokines and muscle-adipose tissue crosstalk. Furthermore, it is intended to particularly focus on the immune-metabolic changes from AT directly mediated by myokines.
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影响因子：
4.9
作者：
Bentzinger CF;Lin S;Romanino K;Castets P;Guridi M;Summermatter S;Handschin C;Tintignac LA;Hall MN;Rüegg MA
通讯作者：
Rüegg MA
DOI：
10.1152/ajpendo.00574.2009
发表时间：
2010-04-01
影响因子：
5.1
作者：
Christiansen, Tore;Paulsen, Soren K.;Richelsen, Bjorn
通讯作者：
Richelsen, Bjorn
影响因子：
3.3
作者：
Castellani, Laura;Perry, Christopher G. R.;Wright, David C.
通讯作者：
Wright, David C.
影响因子：
6.1
作者：
Cinkajzlová A;Mráz M;Lacinová Z;Kloučková J;Kaválková P;Kratochvílová H;Trachta P;Křížová J;Haluzíková D;Škrha J;Papežová H;Haluzík M
通讯作者：
Haluzík M
影响因子：
4
作者：
Batista, M. L., Jr.;Neves, R. X.;Seelaender, M.
通讯作者：
Seelaender, M.