Sequence similarities between human immunodeficiency virus gp41 and paramyxovirus fusion proteins.
Sequence similarities between human immunodeficiency virus gp41 and paramyxovirus fusion proteins.
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人类免疫缺陷病毒 gp41 和副粘病毒融合蛋白之间的序列相似性。
DOI：
10.1089/aid.1987.3.245
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发表时间：
1987
影响因子：
1.5
通讯作者：
Hoxie,JA
中科院分区：
文献类型：
--
作者：
Gonzalez-Scarano,F;Waxham,MN;Ross,AM;Hoxie,JA
Cell fusion is a characteristic cytopathic effect induced by the human immunodeficiency virus (HIV) that leads to the formation of syncytia between infected lymphocytes. Although this process has been shown to occur following the specific binding of the 110–120 kD externalized envelope molecule of the virus with the CD4 glycoprotein, the region of the HIV envelope that directly mediates cell fusion is unknown. In an attempt to identify this fusion domain, we compared the amino acid sequences from the envelope molecules of several HIV isolates to the fusion proteins of paramyxoviruses. We found that the amino terminal region of the HIV transmembrane protein gp41 had a striking degree of similarity with the fusion domain of the respiratory syncytial virus. Moreover, similar sequences were noted in the fusion proteins of other paramyxoviruses and the transmembrane envelope proteins of a variety of lentiviruses suggesting that a functional relationship exists between these glycoproteins. This finding indicates that the amino terminal region of the HIV gp41 molecule may mediate cell fusion for this virus, and could be an important target in the design of immunologic strategies for the prevention of HIV infection in vivo.
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影响因子：
56.9
作者：
MCDOUGAL, JS;KENNEDY, MS;NICHOLSON, JKA
通讯作者：
NICHOLSON, JKA
影响因子：
56.9
作者：
KOWALSKI, M;POTZ, J;SODROSKI, J
通讯作者：
SODROSKI, J
麻疹病毒 F1 多肽的分离和表征：与其他副粘病毒融合蛋白的比较。
影响因子：
3.7
作者：
T. Varsanyi;H. Jörnvall;E. Norrby
通讯作者：
E. Norrby
麻疹疫苗接种的副反应提示阿图斯现象。
影响因子：
158.5
作者：
F. Buser
通讯作者：
F. Buser
影响因子：
3.7
作者：
K. Rushlow;K. Olsen;G. Stiegler;S. Payne;R. Montelaro;C. Issel
通讯作者：
K. Rushlow;K. Olsen;G. Stiegler;S. Payne;R. Montelaro;C. Issel