Concurrent saturation transfer contrast in in vivo brain by a uniform magnetization transfer MRI.
Concurrent saturation transfer contrast in in vivo brain by a uniform magnetization transfer MRI.
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DOI：
10.1016/j.neuroimage.2014.03.040
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发表时间：
2014-07-15
期刊：
影响因子：
5.7
通讯作者：
Regatte RR
中科院分区：
文献类型：
--
作者：
Lee JS;Xia D;Ge Y;Jerschow A;Regatte RR
磁共振化学交换饱和转移(CEST)和磁化转移(MT)对比剂的发展使体内代谢产物和生物标志物的检测得到了加强。在脑MRI中，由于对比机制的频率响应重叠，CEST和MT造影剂之间的分离特别困难。我们在这里证明了MT和CEST对比可以通过所谓的统一MT(UMT)技术在大脑中分离，从而打开了解决这一领域长期存在的歧义的大门。这些方法可能有助于跟踪重要的内源性代谢物，并提供对神经和神经退行性疾病的更好理解。在健康志愿者和多发性硬化症患者的脑白质和灰质区显示的例子表明，MT在大脑中的作用是不对称的，UMT方法可以使它们统一。
The development of chemical exchange saturation transfer (CEST) and magnetization transfer (MT) contrast in MRI have enabled the enhanced detection of metabolites and biomarkers in vivo. In brain MRI, the separation between CEST and MT contrast has been particularly difficult due to overlaps in the frequency responses of the contrast mechanisms. We demonstrate here that MT and CEST contrast can be separated in the brain by the so-called uniform-MT (uMT) technique, thus opening the door to addressing long-standing ambiguities in this field. These methods could be useful for keeping track of important endogenous metabolites and for providing an improved understanding of neurological and neurodegenerative disorders. Examples are shown from white and gray matter regions in healthy volunteers and patients with multiple sclerosis, which demonstrated that the MT effects in the brain were asymmetric and that the uMT method could make them uniform.
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