Circadian Clock-Controlled Checkpoints in the Pathogenesis of Complex Disease.
Circadian Clock-Controlled Checkpoints in the Pathogenesis of Complex Disease.
复制标题
复杂疾病发病机制中生物钟控制的检查点
DOI：
10.3389/fgene.2021.721231
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发表时间：
2021
影响因子：
3.7
通讯作者：
Biological Rhythm Academic Consortium in Chongqing (BRACQ)
中科院分区：
文献类型：
--
作者：
Li MD;Xin H;Yuan Y;Yang X;Li H;Tian D;Zhang H;Zhang Z;Han TL;Chen Q;Duan G;Ju D;Chen K;Deng F;He W;Biological Rhythm Academic Consortium in Chongqing (BRACQ)
生物钟将生理、代谢和行为与环境光照的24小时周期协调起来。在过去二十年里，生物钟调控器官生理和代谢的基本机制得到了迅速阐释。在此，我们回顾了与复杂疾病相关的六个以上器官系统中的生物钟网络，这些疾病多围绕代谢紊乱展开，并试图提出在复杂疾病发病机制中受生物钟控制的关键调节分子（称为生物钟控制检查点）。其中包括肝脏和肌肉组织中的生物钟控制核受体等生物钟控制检查点，以及脉管系统中的趋化因子和黏附分子。尽管取得的进展令人鼓舞，但在机制方面仍存在许多空白有待填补。未来的研究应着重制定针对肝脏等特征明确器官的时间依赖性给药策略，并阐明心脏、血液、周围神经元和生殖系统等目前研究较少的器官系统中的基本生物钟生物学原理。
The circadian clock coordinates physiology, metabolism, and behavior with the 24-h cycles of environmental light. Fundamental mechanisms of how the circadian clock regulates organ physiology and metabolism have been elucidated at a rapid speed in the past two decades. Here we review circadian networks in more than six organ systems associated with complex disease, which cluster around metabolic disorders, and seek to propose critical regulatory molecules controlled by the circadian clock (named clock-controlled checkpoints) in the pathogenesis of complex disease. These include clock-controlled checkpoints such as circadian nuclear receptors in liver and muscle tissues, chemokines and adhesion molecules in the vasculature. Although the progress is encouraging, many gaps in the mechanisms remain unaddressed. Future studies should focus on devising time-dependent strategies for drug delivery and engagement in well-characterized organs such as the liver, and elucidating fundamental circadian biology in so far less characterized organ systems, including the heart, blood, peripheral neurons, and reproductive systems.
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DOI：
10.1073/pnas.1619320114
发表时间：
2017-05-16
影响因子：
11.1
作者：
Anafi, Ron C.;Francey, Lauren J.;Kim, Junhyong
通讯作者：
Kim, Junhyong
影响因子：
--
作者：
Chatterjee S;Ma K
通讯作者：
Ma K
影响因子：
29
作者：
Chaix A;Lin T;Le HD;Chang MW;Panda S
通讯作者：
Panda S
影响因子：
1.6
作者：
Arrebola F;Abecia JA
通讯作者：
Abecia JA
影响因子：
15.9
作者：
Adlanmerini, Marine;Nguyen, Hoang C. B.;Lazar, Mitchell A.
通讯作者：
Lazar, Mitchell A.