MRI measurements of Blood-Brain Barrier function in dementia: A review of recent studies.
MRI measurements of Blood-Brain Barrier function in dementia: A review of recent studies.
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DOI：
10.1016/j.neuropharm.2017.10.034
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发表时间：
2018-05-15
影响因子：
4.7
通讯作者：
Caprihan A
中科院分区：
文献类型：
--
作者：
Raja R;Rosenberg GA;Caprihan A
血脑屏障（BBB）分隔体循环和脑，调节大多数分子的转运以保护脑微环境。多个结构和功能组件保持BBB的完整性。有几种成像方式可用于研究BBB的破坏。然而，在血管性认知障碍和阿尔茨海默病中发生的血脑屏障渗漏的细微变化还没有得到很好的研究。动态对比增强磁共振成像（DCE-MRI）是最广泛采用的非侵入性成像技术，用于评估血脑屏障崩溃。它被用作具有大渗透性泄漏的各种疾病的重要标志物，例如脑肿瘤和多发性硬化症，以及慢性血管疾病和痴呆症中更微妙的破坏。BBB的DCE-MRI分析包括无模型参数和使用药代动力学建模的定量参数。我们回顾了痴呆患者血脑屏障破坏的MRI研究。在测量微妙的血脑屏障的变化和最先进的技术的国家的挑战进行了初步研究。随后，一个系统的审查比较方法，从最近的体内MRI研究。回顾了与微妙的BBB渗透性测量相关的各种因素，例如DCE-MRI采集参数、动脉输入评估、T1标测和数据分析方法，重点是找到最佳技术。最后，在不同的研究和不同的大脑区域之间比较了痴呆症中报告的BBB通透性值。我们的结论是，可靠的测量低水平BBB渗透性的网站仍然是一个困难的问题，数据采集和定量分析的方法标准化是必要的。
Blood-brain barrier (BBB) separates the systemic circulation and the brain, regulating transport of most molecules to protect the brain microenvironment. Multiple structural and functional components preserve the integrity of the BBB. Several imaging modalities are available to study disruption of the BBB. However, the subtle changes in BBB leakage that occurs in vascular cognitive impairment and Alzheimer’s disease have been less well studied. Dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) is the most widely adopted non-invasive imaging technique for evaluating BBB breakdown. It is used as a significant marker for a wide variety of diseases with large permeability leaks, such as brain tumors and multiple sclerosis, to more subtle disruption in chronic vascular disease and dementia. DCE-MRI analysis of BBB includes both model-free parameters and quantitative parameters using pharmacokinetic modelling. We review MRI studies of BBB breakdown in dementia. The challenges in measuring subtle BBB changes and the state of the art techniques are initially examined. Subsequently, a systematic review comparing methodologies from recent in-vivo MRI studies is presented. Various factors related to subtle BBB permeability measurement such as DCE-MRI acquisition parameters, arterial input assessment, T1 mapping and data analysis methods are reviewed with the focus on finding the optimal technique. Finally, the reported BBB permeability values in dementia are compared across different studies and across various brain regions. We conclude that reliable measurement of low-level BBB permeability across sites remains a difficult problem and a standardization of the methodology for both data acquisition and quantitative analysis is required.
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影响因子：
8.3
作者：
Hartz AM;Bauer B;Soldner EL;Wolf A;Boy S;Backhaus R;Mihaljevic I;Bogdahn U;Klünemann HH;Schuierer G;Schlachetzki F
通讯作者：
Schlachetzki F
影响因子：
2.7
作者：
Barnes SR;Ng TS;Santa-Maria N;Montagne A;Zlokovic BV;Jacobs RE
通讯作者：
Jacobs RE
影响因子：
6.3
作者：
Cramer, Stig P.;Larsson, Henrik B. W.
通讯作者：
Larsson, Henrik B. W.
影响因子：
3.3
作者：
Johnson, G;Wetzel, SG;Tofts, PS
通讯作者：
Tofts, PS
影响因子：
2.5
作者：
Armitage, Paul A.;Farrall, Andrew J.;Wardlaw, Joanna M.
通讯作者：
Wardlaw, Joanna M.