Social influences on neurobiology and behavior: epigenetic effects during development.
Social influences on neurobiology and behavior: epigenetic effects during development.
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DOI：
10.1016/j.psyneuen.2010.06.005
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发表时间：
2011-04
影响因子：
3.7
通讯作者：
Champagne, F. A.
中科院分区：
文献类型：
--
作者：
Curley, J. P.;Jensen, C. L.;Mashoodh, R.;Champagne, F. A.
社会环境的质量可以对神经系统的发育和活动产生深远的影响，并对许多行为和生理反应产生影响，包括情绪的表达。虽然发生在发育早期的社会经历可能对发育中的大脑有特别的影响，但在青少年和成年早期，这些神经回路具有持续的可塑性。在这篇综述中，我们探讨了来自啮齿动物研究的证据，这些证据说明了神经系统发育过程中的社会调节，特别强调了那些观察到长期影响的系统。对于这些系统响应环境而持续发生动态变化的一个可能解释是表观遗传机制的参与，在这里，我们讨论了最近的研究，这些研究支持这些机制在调节社会经验、基因表达、神经生物学变化和行为变异之间的联系方面的作用。这些文献提出了一些关键问题，包括神经系统之间的相互作用、神经和行为变化之间的一致性、两性二态性的影响、考虑个体差异对社会环境的反应的重要性，以及表观遗传学视角在促进我们对导致心理健康变化的途径的理解方面的潜力。
The quality of the social environment can have profound influences on the development and activity of neural systems with implications for numerous behavioral and physiological responses, including the expression of emotionality. Though social experiences occurring early in development may be particularly influential on the developing brain, there is continued plasticity within these neural circuits amongst juveniles and into early adulthood. In this review, we explore the evidence derived from studies in rodents which illustrates the social modulation during development of neural systems, with a particular emphasis on those systems in which a long-term effect is observed. One possible explanation for the persistence of dynamic changes in these systems in response to the environment is the involvement of epigenetic mechanisms, and here we discuss recent studies which support the role of these mechanisms in mediating the link between social experiences, gene expression, neurobiological changes, and behavioral variation. This literature raises critical questions about the interaction between neural systems, the concordance between neural and behavioral changes, sexual dimorphism in effects, the importance of considering individual differences in response to the social environment, and the potential of an epigenetic perspective in advancing our understanding of the pathways leading to variations in mental health.
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DOI：
10.1523/jneurosci.5057-08.2009
发表时间：
2009-02-04
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Arai JA;Li S;Hartley DM;Feig LA
通讯作者：
Feig LA
影响因子：
16.2
作者：
Bielsky, IF;Hu, SB;Young, LJ
通讯作者：
Young, LJ
影响因子：
4.8
作者：
Avishai-Eliner, S;Eghbal-Ahmadi, M;Baram, TZ
通讯作者：
Baram, TZ
影响因子：
3.4
作者：
Bredy, Timothy W.;Brown, Richard E.;Meaney, Michael J.
通讯作者：
Meaney, Michael J.
影响因子：
5.3
作者：
Bhansali, Punita;Dunning, Jane;Schmauss, Claudia
通讯作者：
Schmauss, Claudia