Experiential, autonomic, and neural responses during threat anticipation vary as a function of threat intensity and neuroticism.
Experiential, autonomic, and neural responses during threat anticipation vary as a function of threat intensity and neuroticism.
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DOI：
10.1016/j.neuroimage.2010.11.040
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发表时间：
2011-03-01
期刊：
影响因子：
5.7
通讯作者：
Gross JJ
中科院分区：
文献类型：
--
作者：
Drabant EM;Kuo JR;Ramel W;Blechert J;Edge MD;Cooper JR;Goldin PR;Hariri AR;Gross JJ
预期的情绪反应在个人为即将到来的挑战做好准备方面起着至关重要的作用。它们通过触发行为、自主神经和神经反应系统的一系列协调变化来做到这一点。在本研究中，我们研究了不同程度的预期焦虑对生物行为的影响，使用了一个电击预期任务，在这个任务中，不可预测的电击受到威胁，并以不同的间隔和强度（安全、中等、强）传递到手腕上。这允许对预期焦虑反应的动态范围进行调查。在两项研究中，分别有95名和51名健康女性参与者在提供焦虑体验和皮电反应的连续评分（研究1）和fMRI BOLD神经成像（研究2）期间接受了这种休克预期任务。结果显示焦虑体验和皮肤电反应呈阶梯反应模式。与安全试验相比，一些脑区对休克预期表现出强劲的反应，包括下丘脑、导水管周围灰质、尾状核、中央前回、丘脑、岛、腹外侧PFC、背内侧PFC和ACC。这些区域的一部分，包括双侧脑岛、ACC和额下回，表现出从安全到中等到强的线性反应模式。这些反应被神经质的个体差异所调节，例如，那些神经质程度高的人在整个任务中表现出夸大的焦虑体验，并且在大脑区域的一个子集中，从中等到强烈的大脑激活减少了。这些发现表明，神经质的个体差异可能会影响对预期威胁的敏感性，并为神经质通过失调的预期反应增加发展为焦虑症风险的机制提供了新的见解。
Anticipatory emotional responses play a crucial role in preparing individuals for impending challenges. They do this by triggering a coordinated set of changes in behavioral, autonomic, and neural response systems. In the present study, we examined the biobehavioral impact of varying levels of anticipatory anxiety, using a shock anticipation task in which unpredictable electric shocks were threatened and delivered to the wrist at variable intervals and intensities (safe, medium, strong). This permitted investigation of a dynamic range of anticipatory anxiety responses. In two studies, 95 and 51 healthy female participants, respectively, underwent this shock anticipation task while providing continuous ratings of anxiety experience and electrodermal responding (Study 1) and during fMRI BOLD neuroimaging (Study 2). Results indicated a step-wise pattern of responding in anxiety experience and electrodermal responses. Several brain regions showed robust responses to shock anticipation relative to safe trials, including the hypothalamus, periaqueductal gray, caudate, precentral gyrus, thalamus, insula, ventrolateral PFC, dorsomedial PFC, and ACC. A subset of these regions demonstrated a linear pattern of increased responding from safe to medium to strong trials, including the bilateral insula, ACC, and inferior frontal gyrus. These responses were modulated by individual differences in neuroticism, such that those high in neuroticism showed exaggerated anxiety experience across the entire task, and reduced brain activation from medium to strong trials in a subset of brain regions. These findings suggest that individual differences in neuroticism may influence sensitivity to anticipatory threat and provide new insights into the mechanism through which neuroticism may confer risk for developing anxiety disorders via dysregulated anticipatory responses.
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影响因子：
1.9
作者：
Canli, T;Zhao, Z;Gabrieli, JDE
通讯作者：
Gabrieli, JDE
影响因子：
5.7
作者：
Chua, P;Krams, M;Dolan, R
通讯作者：
Dolan, R
影响因子：
2
作者：
Cheng, Dominic T.;Richards, Jennifer;Helmstetter, Fred J.
通讯作者：
Helmstetter, Fred J.
影响因子：
2.6
作者：
DIMBERG, U
通讯作者：
DIMBERG, U
DOI：
10.1073/pnas.0800374105
发表时间：
2008-06-10
影响因子：
11.1
作者：
Cheng, Dominic T.;Disterhoft, John F.;Desmond, John E.
通讯作者：
Desmond, John E.