Genetic polymorphisms in apoptosis-related genes and the prognosis of hepatocellular carcinoma.
Genetic polymorphisms in apoptosis-related genes and the prognosis of hepatocellular carcinoma.
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凋亡相关基因的遗传多态性与肝细胞癌的预后。
DOI：
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发表时间：
2015-09
影响因子：
5.3
通讯作者：
Yu Lon
中科院分区：
文献类型：
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作者：
Yu Guo-Peng;Xiao Qian-Yi;Shi Zhu-Qing;Tang Li-Sha;Ma Xiao-Pin;Zhang Lu-Yao;Chen Hai-Tao;Wang Wen-Jia;Zhang Peng-Yin;Ding Dong-Lin;Huang Hui-Xing;Saiyin Hexige;Chen Tao-Yang;Lu Pei-Xin;Wang Neng-Jin;Yu Hong-Jie;Sun Jie-Lin;Zheng S Lilly;Xu Jian-Feng;Yu Lon
细胞凋亡途径在肝细胞癌（HCC）的重要过程中起着重要的控制作用。在目前的研究中，我们的目的是确定是否凋亡基因相关的多态性改变肝癌的预后。我们使用来自362例接受手术切除的HCC肿瘤患者的血液样本的DNA，对凋亡途径中的10个核心基因（TP53、TP53INP1、TP53BP1、CDKN2A、CDKN1A、CDKN1B、MDM2、BAX、CCDN 1和BCL 2）的16个单核苷酸多态性（SNP）进行基因分型。采用考克斯比例风险模型评估这10个基因的基因型/单倍型与HCC患者总生存期（OS）之间的关系。我们发现了一个CDKN1B单倍型CCT/ACT单因素分析显示，与常见单倍型ACT/CTT相比，rs36228499 C> A、rs34330 C> T和rs2066827 T> G构建的单倍型ACT/CTT与HCC患者OS降低显著相关，多因素分析（P = 0.006，HR = 1.224，95%CI：1.059-1.413）。我们还发现TP53BP1中的两个SNP（rs560191 G> C和rs2602141 T> G）显示与HCC患者的OS降低略微显著相关。然而，没有其他SNPs或单倍型与HCC OS显著相关。我们的研究结果说明了CDKN1B单倍型作为手术切除肿瘤的HCC患者的预后标志物的潜在用途。
The apoptotic pathway is important in the control of vital processes of hepatocellular carcinoma (HCC). In the current study, we aimed to determine whether apoptotic gene-related polymorphisms modified HCC prognosis. We genotyped 16 single nucleotide polymorphisms (SNPs) in 10 core genes (TP53, TP53INP1, TP53BP1, CDKN2A, CDKN1A, CDKN1B, MDM2, BAX, CCDN1 and BCL2) in the apoptotic pathway by using DNA from blood samples of 362 HCC patients receiving surgical resection of HCC tumor. The associations between genotypes/haplotypes of the 10 genes and overall survival (OS) of HCC patients were assessed using the Cox proportional hazards model. We found one CDKN1B haplotype CCT/ACT (constructed by rs36228499 C>A, rs34330 C>T and rs2066827 T>G) significantly associated with decreased OS of HCC patients, compared to the common haplotype ACT/CTT both in univariate analysis (P=0.013, HR=1.198, 95% CI: 1.039-1.381) and multivariate analysis (P=0.006, HR=1.224, 95% CI: 1.059-1.413). We also find two SNPs (rs560191 G>C and rs2602141 T>G) in TP53BP1 shown to be marginally significantly associated with decreased OS of HCC patients. However, none of the other SNPs or haplotypes were significantly associated with HCC OS. Our results illustrated the potential use of CDKN1B haplotype as a prognostic marker for HCC patients with surgical resection of tumor.
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DOI：
10.1016/s0360-3016(03)00637-0
发表时间：
2003-11-01
影响因子：
7
作者：
Schmitz, A;Bayer, J;Thomas, G
通讯作者：
Thomas, G
p73 外显子 2 G4C14-to-A4T14 多态性与中国人群肝细胞癌风险的关联
影响因子：
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作者：
Deng B;Liu F;Wei Y;Luo L;Chen X;Yan L;Li B
通讯作者：
Li B
影响因子：
10.5
作者：
POLYAK, K;KATO, JY;KOFF, A
通讯作者：
KOFF, A
影响因子：
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作者：
J. Kountouras;C. Zavos;D. Chatzopoulos
通讯作者：
J. Kountouras;C. Zavos;D. Chatzopoulos
影响因子：
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作者：
Wang, Xiao Qi;Lui, Eric Lik Hang;Fan, Sheung Tat
通讯作者：
Fan, Sheung Tat