Different populations of melanocytes are present in hair follicles and epidermis.
Different populations of melanocytes are present in hair follicles and epidermis.
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毛囊和表皮中存在不同的黑素细胞群。
DOI：
10.1111/j.1600-0749.1996.tb00122.x
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Bystryn,JC
中科院分区：
文献类型：
--
作者：
Tobin,DJ;Bystryn,JC
Melanocytes in human skin reside both in the epidermis and in the matrix and outer root sheath of anagen hair follicles. Comparative study of melanocytes in these different locations has been difficult as hair follicle melanocytes could not be cultured. In this study we used a recently described method of growing hair follicle melanocytes to characterize and compare hair follicle and epidermal melanocytes in the scalp of the same individual. Three morphologically and antigenically distinct types of melanocytes were observed in primary culture. These included (1) moderately pigmented and polydendritic melanocytes derived from epidermis; (2) small, bipolar, amelanotic melanocytes; and (3) large, intensely pigmented melanocytes; the latter two were derived from hair follicles. The three sub‐populations of cells all reacted with melanocyte‐specific monoclonal antibody. Epidermal and amelanotic hair follicle melanocytes proliferated well in culture, whereas the intensely pigmented hair follicle melanocytes did not. Amelanotic hair follicle melanocytes differed from epidermal melanocytes in being less differentiated, and they expressed less mature melanosome antigens. In addition, hair follicle melanocytes expressed some antigens associated with alopecia areata, but not antigens associated with vitiligo, whereas the reverse was true for epidermal melanocytes. Thus, antigenically different populations of melanocytes are present in epidermis and hair follicle. This could account for the preferential destruction of hair follicle melanocytes in alopecia areata and of epidermal melanocytes in vitiligo.
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DOI：
10.1111/1523-1747.ep12375477
发表时间：
1994
期刊：
The Journal of investigative dermatology
影响因子：
--
作者：
Tobin,DJ;Orentreich,N;Fenton,DA;Bystryn,JC
通讯作者：
Bystryn,JC
影响因子：
--
作者：
ATKINSON, B;ERNST, CS;KOPROWSKI, H
通讯作者：
KOPROWSKI, H
DOI：
10.1111/1523-1747.ep12613573
发表时间：
1995
期刊：
The Journal of investigative dermatology
影响因子：
--
作者：
Desmond J. Tobin;Stephen R. Colen;Jean-Claude Bystryn
通讯作者：
Desmond J. Tobin;Stephen R. Colen;Jean-Claude Bystryn
紫外线照射后毛囊外根鞘中的无色素细胞被激活。
DOI：
10.1038/jid.1962.97
发表时间：
1962
期刊：
The Journal of investigative dermatology
影响因子：
--
作者：
R. Staricco;A. MILLER
通讯作者：
A. MILLER
Cloudman S-91 小鼠黑色素瘤细胞培养物中酪氨酸酶的α-黑色素细胞刺激激素调节。
DOI：
--
发表时间：
1987
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Fuller,BB;Lunsford,JB;Iman,DS
通讯作者：
Iman,DS