Respiratory viruses are associated with serum metabolome among infants hospitalized for bronchiolitis: A multicenter study.
Respiratory viruses are associated with serum metabolome among infants hospitalized for bronchiolitis: A multicenter study.
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DOI：
10.1111/pai.13296
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发表时间：
2020-10
期刊：
影响因子：
--
通讯作者：
Hasegawa K
中科院分区：
文献类型：
--
作者：
Fujiogi M;Camargo CA Jr;Raita Y;Bochkov YA;Gern JE;Mansbach JM;Piedra PA;Hasegawa K
细支气管炎是美国婴儿住院的主要原因。越来越多的证据支持细支气管炎的异质性。然而，人们对主要呼吸道病毒（及其种类）、宿主全身代谢和疾病病理学之间的相互关系知之甚少。在一项正在进行的多中心前瞻性队列研究中，我们分析了 113 名因细支气管炎住院的婴儿（63 名仅 RSV、21 名 RV-A 和 29 名 RV-C）的血清代谢组。我们使用稀疏偏最小二乘判别分析确定了在 RSV-RV-A 和 RSV-RV-C 比较中最具辨别力的血清代谢物。然后我们研究了歧视性代谢物与急性和慢性结果之间的关联。在 113 名患有细支气管炎的婴儿中，我们测量了 639 种代谢物。两次比较中的血清代谢组谱均不同（Ppermutation<0.05）。在 RSV-RV-A 比较中，我们确定了 30 种有区别的代谢物，主要存在于脂质代谢途径中（例如鞘脂和肉碱）。在多变量模型中，这些代谢物与临床结果的风险显着相关（例如，二十三酰鞘磷脂，3 岁时反复喘息的 OR = 1.50；95%CI 1.05–2.15）。在 RSV-RV-C 比较中，有区别的代谢物也主要涉及脂质代谢（例如甘油磷酸胆碱 [GPC]、12,13-DiHome）。这些代谢物也与结果风险显着相关（例如，1-硬脂酰-2-亚油酰-GPC，住院期间使用正压通气的 OR=0.47；95%CI 0.28–0.78）。呼吸道病毒及其物种具有独特的血清代谢组特征，与毛细支气管炎急性和慢性发病的不同风险相关。我们的研究结果推进了对病毒、宿主系统反应和细支气管炎病理学之间复杂相互关系的研究。
Bronchiolitis is the leading cause of infant hospitalizations in the U.S. Growing evidence supports the heterogeneity of bronchiolitis. However, little is known about the interrelationships between major respiratory viruses (and their species), host systemic metabolism, and disease pathobiology. In an ongoing multicenter prospective cohort study, we profiled the serum metabolome in 113 infants (63 RSV-only, 21 RV-A, and 29 RV-C) hospitalized with bronchiolitis. We identified serum metabolites that are most discriminatory in the RSV—RV-A and RSV—RV-C comparisons using sparse partial least squares discriminant analysis. We then investigated the association between discriminatory metabolites with acute and chronic outcomes. In 113 infants with bronchiolitis, we measured 639 metabolites. Serum metabolome profiles differed in both comparisons (Ppermutation<0.05). In the RSV—RV-A comparison, we identified 30 discriminatory metabolites, predominantly in lipid metabolism pathways (e.g., sphingolipids and carnitines). In multivariable models, these metabolites were significantly associated with the risk of clinical outcomes (e.g., tricosanoyl sphingomyelin, OR for recurrent wheezing at age 3 years = 1.50; 95%CI 1.05–2.15). In the RSV—RV-C comparison, the discriminatory metabolites were also primarily involved in lipid metabolism (e.g., glycerophosphocholines [GPCs], 12,13-DiHome). These metabolites were also significantly associated with the risk of outcomes (e.g., 1-stearoyl-2-linoleoyl-GPC, OR for positive pressure ventilation use during hospitalization=0.47; 95%CI 0.28–0.78). Respiratory viruses and their species had distinct serum metabolomic signatures that are associated with differential risks of acute and chronic morbidities of bronchiolitis. Our findings advance research into the complex interrelations between viruses, host systemic response, and bronchiolitis pathobiology.
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影响因子：
--
作者：
Sturgill JL
通讯作者：
Sturgill JL
影响因子：
14.2
作者：
Toivonen, Laura;Camargo, Carlos A., Jr.;Hasegawa, Kohei
通讯作者：
Hasegawa, Kohei
影响因子：
8
作者：
Ralston, Shawn L.;Lieberthal, Allan S.;Hernandez-Cancio, Sinsi
通讯作者：
Hernandez-Cancio, Sinsi
影响因子：
2.6
作者：
Scott, Jeremy A.;Grasemann, Hartmut
通讯作者：
Grasemann, Hartmut
DOI：
10.1016/j.jaci.2018.08.043
发表时间：
2019-04
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
Dumas O;Hasegawa K;Mansbach JM;Sullivan AF;Piedra PA;Camargo CA Jr
通讯作者：
Camargo CA Jr