Sphingolipids and their enigmatic role in asthma.
Sphingolipids and their enigmatic role in asthma.
复制标题
DOI：
10.1016/j.jbior.2018.09.001
复制
发表时间：
2018-12
影响因子：
--
通讯作者：
Sturgill JL
中科院分区：
文献类型：
--
作者：
Sturgill JL
哮喘被定义为肺部的一种慢性炎症状态，其特征是发作性呼吸短促，并伴有呼气喘息和咳嗽。哮喘是全球一个严重的公共卫生问题，估计发病率超过3亿。哮喘是一种复杂的疾病，表现为基因和环境相互作用的疾病。鞘磷脂是一类独特的脂类，参与了一系列生物学功能，从作为关键的细胞膜脂质到作为关键的信号分子。到目前为止，鞘脂已经在各种人类疾病中进行了研究，从神经疾病到癌症，从感染到自身免疫。本综述将侧重于鞘脂在哮喘发生和病理中的作用，特别是肥大细胞鞘脂生物学的作用。
Asthma is defined as a chronic inflammatory condition in the lung and is characterized by episodic shortness of breath with expiratory wheezing and cough. Asthma is a serious public health concern globally with an estimated incidence over 300 million. Asthma is a complex disease in that it manifests as disease of gene and environmental interactions. Sphingolipids are a unique class of lipids involved in a host of biological functions ranging from serving as key cellular membrane lipids to acting as critical signaling molecules. To date sphingolipids have been studied across various human conditions ranging from neurological disorders to cancer to infection to autoimmunity. This review will focus on the role of sphingolipids in asthma development and pathology with particular focus on the role of mast cell sphingolipid biology.
登录
查看更多内容
影响因子：
6.2
作者：
Hait NC;Avni D;Yamada A;Nagahashi M;Aoyagi T;Aoki H;Dumur CI;Zelenko Z;Gallagher EJ;Leroith D;Milstien S;Takabe K;Spiegel S
通讯作者：
Spiegel S
影响因子：
7.2
作者：
Bodas, Manish;Min, Taehong;Vij, Neeraj
通讯作者：
Vij, Neeraj
ORM家族蛋白介导鞘脂稳态。
影响因子：
64.8
作者：
Breslow, David K.;Collins, Sean R.;Bodenmiller, Bernd;Aebersold, Ruedi;Simons, Kai;Shevchenko, Andrej;Ejsing, Christer S.;Weissman, Jonathan S.
通讯作者：
Weissman, Jonathan S.
影响因子：
168.9
作者：
Guarnieri, Michael;Balmes, John R.
通讯作者：
Balmes, John R.
影响因子：
3.4
作者：
Cheng, Qi;Shang, Yunxiao
通讯作者：
Shang, Yunxiao