Interleaved fluid-attenuated inversion recovery (FLAIR) MRI and deuterium metabolic imaging (DMI) on human brain in vivo.
Interleaved fluid-attenuated inversion recovery (FLAIR) MRI and deuterium metabolic imaging (DMI) on human brain in vivo.
复制标题
在体人脑的交错液体衰减反转恢复（FLAIR）MRI和氘代谢成像（DIM）。
DOI：
10.1002/mrm.29196
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发表时间：
2022-07
影响因子：
3.3
通讯作者：
de Graaf, Robin A.
中科院分区：
文献类型：
--
作者：
Liu, Yanning;De Feyter, Henk M.;Fulbright, Robert K.;McIntyre, Scott;Nixon, Terence W.;de Graaf, Robin A.
关键词：
旨在通过交错MRI和氘代谢成像采集工作流程将氘代谢成像（氘代谢成像）与临床MRI集成。通过硬件和脉冲序列修改实现了交错MRI-MRI，并以液体衰减反转恢复（FLAIR）MRI为例证明了其性能。通过将2 H激励和采集时间窗口交错到FLAIR方法中提出的固有延迟周期中，开发了交错FLAIR-100。使用定制的硬件单元将所有2 H MR信号上变频到1H Larmor频率，该硬件单元还实现了输出信号的实时频率和相位锁定。交错测量进行了比较，直接测量在体模和在人体大脑中。交错MRI-MRI采集策略允许在与仅FLAIR MRI采集相同的扫描时间内同时检测FLAIR MRI和MRI。体模和体内数据均表明，使用交错MRI-MRI可保留MR图像质量、MRI灵敏度以及信息内容。交错MRI-MRI技术可用于扩展临床MRI协议，从而为MR成像对比提供代谢成分，而不会影响患者舒适度或扫描时间。
To integrate Deuterium Metabolic Imaging (DMI) with clinical MRI through an interleaved MRI and DMI acquisition workflow. Interleaved MRI-DMI was enabled with hardware and pulse sequence modifications, and the performance was demonstrated using Fluid-attenuated inversion recovery (FLAIR) MRI as an example. Interleaved FLAIR-DMI was developed by interleaving the 2H excitation and acquisition time windows into the intrinsic delay periods presented in the FLAIR method. All 2H MR signals were up-converted to the 1H Larmor frequency using a custom-built hardware unit, which also achieved frequency and phase locking of the output signal in real-time. The interleaved measurements were compared with direct measurements both in phantom and in the human brain in vivo. The interleaved MRI-DMI acquisition strategy allowed simultaneous detection of FLAIR MRI and DMI in the same scan time as a FLAIR-only MRI acquisition. Both phantom and in vivo data showed that the MR image quality, DMI sensitivity as well as information content were preserved using interleaved MRI-DMI. The interleaved MRI-DMI technology can be used to extend clinical MRI protocols with DMI, thereby offering a metabolic component to the MR imaging contrasts without a penalty on patient comfort or scan time.
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影响因子：
29
作者：
Pavlova NN;Thompson CB
通讯作者：
Thompson CB
影响因子：
2.9
作者：
de Bruin, Paul W.;Koken, Peter;Webb, Andrew G.
通讯作者：
Webb, Andrew G.
影响因子：
1.3
作者：
HAJNAL, JV;DECOENE, B;BYDDER, GM
通讯作者：
BYDDER, GM
影响因子：
6.3
作者：
Lu, Ming;Zhu, Xiao-Hong;Chen, Wei
通讯作者：
Chen, Wei
影响因子：
4.4
作者：
Lu, HZ;Nagae-Poetscher, LM;van Zijl, PCM
通讯作者：
van Zijl, PCM