Sexually dimorphic effects of dietary sugar on lifespan, feeding and starvation resistance in Drosophila.
Sexually dimorphic effects of dietary sugar on lifespan, feeding and starvation resistance in Drosophila.
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DOI：
10.18632/aging.101335
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发表时间：
2017-12-04
期刊：
影响因子：
--
通讯作者：
Alic N
中科院分区：
文献类型：
--
作者：
Chandegra B;Tang JLY;Chi H;Alic N
老年人的寿命和健康受到饮食的强烈影响。喂养黑腹果蝇的高糖饮食已越来越多地被用作实验模型，以了解不健康的当代人类饮食的生理影响。已知一些代谢参数和对营养的生理反应取决于动物的性别。然而，果蝇对高糖饮食的两性二态性反应尚未得到研究。本研究表明，高糖饮食对黑腹果蝇的摄食行为、饥饿抵抗和寿命产生了两性二态效应。雌性在这种饮食中吃得少，而雄性吃得多，这些进食反应可能会产生次要后果。女性比男性更能抵抗高糖饮食带来的饥饿期，这表明女性对过量糖的反应可能是为了在生命早期的食物短缺中生存。同时，女性的寿命更容易受到高糖饮食的有害影响。我们的研究揭示了果蝇对富含糖的食物的反应在性别上的差异，表明果蝇可以作为一个模型来理解人类代谢健康的两性二态特征。
Lifespan and health in older age are strongly influenced by diet. Feeding Drosophila melanogaster diets high in sugar has increasingly been used as an experimental model to understand the physiological effects of unhealthy, contemporary human diets. Several metabolic parameters and physiological responses to nutrition are known to be dependent on the sex of the animal. However, sexual dimorphism in the responses to high-sugar diets in fruit flies has not been examined. Here we show that a high-sugar diet in Drosophila melanogaster elicits sexually dimorphic effects on feeding behaviour, starvation resistance and lifespan. Females feed less on such diets, while males feed more, and these feeding responses may have secondary consequences. Females, more than males, gain the ability to resist periods of starvation from high-sugar diets, indicating that the female response to excess sugar may be geared towards surviving food shortages in early life. At the same time, female lifespan is more susceptible to the detrimental effects of high sugar diets. Our study reveals differences between Drosophila sexes in their responses to sugar-rich diets, indicating the fruit fly could be used as a model to understand the sexually dimorphic features of human metabolic health.
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