Cell Cycle Dysregulation and Renal Fibrosis.
Cell Cycle Dysregulation and Renal Fibrosis.
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DOI：
10.3389/fcell.2021.714320
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发表时间：
2021
影响因子：
5.5
通讯作者：
Liu HF
中科院分区：
文献类型：
--
作者：
Wu YS;Liang S;Li DY;Wen JH;Tang JX;Liu HF
细胞周期的精确调节对于组织的稳态和发育是必不可少的，而细胞周期失调与许多人类疾病相关，包括肾纤维化，这是各种慢性肾脏疾病进展为终末期肾脏疾病的共同过程。在正常生理条件下，大多数肾细胞是停滞在细胞周期G0期的有丝分裂后静止细胞，并且肾细胞更新非常低。由毒素、缺氧和代谢紊乱引起的损伤可刺激肾细胞进入细胞周期，这对于肾再生和肾功能恢复至关重要。然而，更严重或重复的损伤将导致适应性修复不良，表现为细胞周期停滞或肾细胞过度增殖，这两者与肾纤维化密切相关。因此，肾细胞的细胞周期失调是治疗肾纤维化的潜在治疗靶点。本文就健康肾脏和病变肾脏细胞的细胞周期调控进行综述，探讨细胞周期失调在肾纤维化中的作用。更好地了解细胞周期失调在肾纤维化中的作用对于开发阻止肾纤维化进展或促进消退的治疗方法至关重要。
Precise regulation of cell cycle is essential for tissue homeostasis and development, while cell cycle dysregulation is associated with many human diseases including renal fibrosis, a common process of various chronic kidney diseases progressing to end-stage renal disease. Under normal physiological conditions, most of the renal cells are post-mitotic quiescent cells arrested in the G0 phase of cell cycle and renal cells turnover is very low. Injuries induced by toxins, hypoxia, and metabolic disorders can stimulate renal cells to enter the cell cycle, which is essential for kidney regeneration and renal function restoration. However, more severe or repeated injuries will lead to maladaptive repair, manifesting as cell cycle arrest or overproliferation of renal cells, both of which are closely related to renal fibrosis. Thus, cell cycle dysregulation of renal cells is a potential therapeutic target for the treatment of renal fibrosis. In this review, we focus on cell cycle regulation of renal cells in healthy and diseased kidney, discussing the role of cell cycle dysregulation of renal cells in renal fibrosis. Better understanding of the function of cell cycle dysregulation in renal fibrosis is essential for the development of therapeutics to halt renal fibrosis progression or promote regression.
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