Fungal-bacterial interactions and their relevance to oral health: linking the clinic and the bench.
Fungal-bacterial interactions and their relevance to oral health: linking the clinic and the bench.
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DOI：
10.3389/fcimb.2014.00101
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发表时间：
2014
影响因子：
5.7
通讯作者：
Dongari-Bagtzoglou A
中科院分区：
文献类型：
--
作者：
Diaz PI;Strausbaugh LD;Dongari-Bagtzoglou A
高通量测序加速了对口腔微生物组的了解。虽然口腔群落的细菌组分已被广泛表征，但真菌微生物群在口腔中的作用在很大程度上是未知的。真菌和细菌之间的相互作用可能会影响口腔健康，例如白色念珠菌和口腔链球菌之间的协同关系。从这个角度来看，我们讨论了在口腔的背景下，真菌-细菌相互作用的领域的现状。我们强调需要进行纵向临床研究，以同时表征健康和疾病进展期间人类口腔微生物组的细菌和真菌组分。这些研究需要与使用疾病相关模型的调查相结合，以机械地测试在人类中观察到的相关性，并最终确定可作为口腔疾病预防或治疗靶点的真菌-细菌相互作用。
High throughput sequencing has accelerated knowledge on the oral microbiome. While the bacterial component of oral communities has been extensively characterized, the role of the fungal microbiota in the oral cavity is largely unknown. Interactions among fungi and bacteria are likely to influence oral health as exemplified by the synergistic relationship between Candida albicans and oral streptococci. In this perspective, we discuss the current state of the field of fungal-bacterial interactions in the context of the oral cavity. We highlight the need to conduct longitudinal clinical studies to simultaneously characterize the bacterial and fungal components of the human oral microbiome in health and during disease progression. Such studies need to be coupled with investigations using disease-relevant models to mechanistically test the associations observed in humans and eventually identify fungal-bacterial interactions that could serve as preventive or therapeutic targets for oral diseases.
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影响因子：
11
作者：
Duran-Pinedo, Ana E.;Chen, Tsute;Frias-Lopez, Jorge
通讯作者：
Frias-Lopez, Jorge
影响因子：
6.4
作者：
Jorth P;Turner KH;Gumus P;Nizam N;Buduneli N;Whiteley M
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Whiteley M
影响因子：
3.1
作者：
Falsetta, Megan L.;Klein, Marlise I.;Koo, Hyun
通讯作者：
Koo, Hyun
影响因子：
4.4
作者：
Gregoire, S.;Xiao, J.;Koo, H.
通讯作者：
Koo, H.
影响因子：
4.3
作者：
Faust K;Sathirapongsasuti JF;Izard J;Segata N;Gevers D;Raes J;Huttenhower C
通讯作者：
Huttenhower C