Vessel formation. De novo formation of a distinct coronary vascular population in neonatal heart.
Vessel formation. De novo formation of a distinct coronary vascular population in neonatal heart.
复制标题
新生儿心脏中独特冠状血管群的从头形成
DOI：
10.1126/science.1251487
复制
发表时间：
2014-07-04
期刊：
影响因子：
--
通讯作者：
Zhou B
中科院分区：
文献类型：
--
作者：
Tian X;Hu T;Zhang H;He L;Huang X;Liu Q;Yu W;He L;Yang Z;Yan Y;Yang X;Zhong TP;Pu WT;Zhou B
心脏也需要血管为了使新生心脏快速生长，心脏自身的血管也必须生长。研究人员认为，先天存在的胎儿冠状动脉血管扩张导致出生后冠状动脉血管生长。相反，Tian等人现在表明，在大多数情况下，新生儿心脏内形成了全新的血管（参见Burns和Burns的观点）。这种在出生后产生新的冠状血管的能力可能有一天会帮助研究人员研究如何促进损伤或疾病后的心血管再生。《科学》杂志，本期第90页;另见第28页新生小鼠心脏内新生的冠状血管。[Also出生后的冠状血管被认为是通过在胎儿时期形成的血管的扩张而发育的。使用遗传谱系追踪，我们发现，出生后的冠状动脉血管的相当大的一部分出现在新生小鼠心脏，而不是从预先存在的胚胎血管扩张。我们的数据表明，新生儿内皮细胞在小梁致密化过程中的谱系转换产生了位于心室壁内半部的冠状动脉循环的独特隔室。这种谱系转换发生在出生后的短时间内，并提供了快速扩增冠状动脉血管的有效手段。这种出生后冠状血管生长的机制为理解和刺激损伤和疾病后的心血管再生提供了途径。
The heart needs blood vessels, too For the newborn heart to grow quickly, the heart's own blood vessels must grow as well. Researchers have assumed that preexisting fetal coronary vessels expand to cause this postnatal coronary vascular growth. Instead, Tian et al. now show that, for the most part, brandnew blood vessels form within the neonatal heart (see the Perspective by Burns and Burns). This ability to produce new coronary blood vessels after birth may one day help researchers work out how to promote cardiovascular regeneration after injury or disease. Science, this issue p. 90; see also p. 28 Postnatal coronary vessels arise anew in the neonatal mouse heart from the endocardium. [Also see Perspective by Burns and Burns] The postnatal coronary vessels have been viewed as developing through expansion of vessels formed during the fetal period. Using genetic lineage tracing, we found that a substantial portion of postnatal coronary vessels arise de novo in the neonatal mouse heart, rather than expanding from preexisting embryonic vasculature. Our data show that lineage conversion of neonatal endocardial cells during trabecular compaction generates a distinct compartment of the coronary circulation located within the inner half of the ventricular wall. This lineage conversion occurs within a brief period after birth and provides an efficient means of rapidly augmenting the coronary vasculature. This mechanism of postnatal coronary vascular growth provides avenues for understanding and stimulating cardiovascular regeneration following injury and disease.
登录
查看更多内容
影响因子：
--
作者：
Bennett, HS
通讯作者：
Bennett, HS
影响因子：
11.8
作者：
Katz, Tamar C.;Singh, Manvendra K.;Degenhardt, Karl;Rivera-Feliciano, Jose;Johnson, Randy L.;Epstein, Jonathan A.;Tabin, Clifford J.
通讯作者：
Tabin, Clifford J.
心外膜下内皮细胞侵入胚胎心室壁形成冠状动脉
影响因子：
44.1
作者：
通讯作者：
--
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
4.8
作者：
Elmasri, Harun;Karaaslan, Cagatay;Cataltepe, Sule
通讯作者：
Cataltepe, Sule