Analysis of genomic polymorphism among herpes simplex virus type 2 isolates from four areas of Japan and three other countries
Analysis of genomic polymorphism among herpes simplex virus type 2 isolates from four areas of Japan and three other countries
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日本4个地区及其他3个国家2型单纯疱疹病毒基因组多态性分析
DOI：
10.1002/jmv.1890450305
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发表时间：
1995
影响因子：
12.7
通讯作者：
T. Kawana
中科院分区：
文献类型：
--
作者：
H. Sakaoka;K. Kurita;T. Gouro;Y. Kumamoto;Shigeo Sawada;M. Ihara;T. Kawana
来自日本4个地区和其他3个国家（韩国、瑞典和美国）的307株流行病学无关的单纯疱疹病毒2型（HSV-2）菌株的基因组多态性从97个限制性内切酶位点中筛选出16个变异标记，除此之外，还发现了26个罕见的变异位点。发现16个标记（RE位点）中的5个和4个在来自日本和瑞典的分离物之间以及来自日本和美国的分离物之间具有标记的分离物的频率不同，这表明它们在基因组上彼此不同。通过这种方式，来自四个国家的307株HSV-2分离株可以被分类为68种不同的基因型（分离株数量/基因型数量= 4.5）。有时来自一个国家或两个以上国家的分离株被划分为相同的基因型，这被称为优势基因型。来自日本、瑞典和美国的分离株的最主要基因型分别为基因型30、26（32）和3，表明它们因国家而异。在基因型1和6中，发现分离株的频率在日本和瑞典之间以及日本和美国之间显著不同，分别16个标记中有9个在基因组最远的分离株中不同，每个分离株都是在瑞典和日本获得的。此外，高相关系数（r）在日本分离株中检测到不同对的标记，从那些在瑞典的分离株，这表明，从这两个国家的分离株是进化遥远的。© 1995 Wiley利斯公司
Genomic polymorphism of 307 epidemiologi‐cally unrelated strains of herpes simplex virus type 2 (HSV‐2) from four areas of Japan and three other countries (Korea, Sweden and the U.S.A.) was analysed by using 16 variable markers selected from 97 restriction endonuclease (RE) sites with five REs. In addition to the 16 markers, 26 rare variable RE sites were found in 307 isolates. Five and four of 16 markers (RE sites) were found to differ in the frequency of isolates with the markers between isolates from Japan and Sweden and between those from Japan and the U.S.A., respectively, suggesting that they are genomically different from each other. In this manner, 307 HSV‐2 isolates from four countries could be classified into 68 different genotypes (no. of isolates/no, of genotypes = 4.5). Some isolates from one country or more than two countries at times were classified into the same genotypes, which were referred to as predominant genotypes. The most predominant genotypes for isolates from Japan, Sweden and the U.S.A. were genotypes 30, 26 (32) and 3, respectively, indicating that they are different by the country. In genotypes 1 and 6, the frequency of isolates was found to be significantly different between Japan and Sweden and between Japan and the U.S.A., respectively. Nine out of 16 markers differed in the most genomically distant isolates, each of which was obtained in Sweden and Japan. In addition, high correlation coefficients (r) in the Japanese isolates were detected in different pairs of markers from those in the Swedish isolates, suggesting that isolates from these two countries are evolutionary distant. © 1995 Wiley‐Liss, Inc.
疱疹病毒酶的序列分析表明人类性行为的古老起源。
DOI：
10.1073/pnas.85.8.2658
发表时间：
1988
影响因子：
11.1
作者：
Gentry,GA;Lowe,M;Alford,G;Nevins,R
通讯作者：
Nevins,R
单纯疱疹病毒 DNA 的限制性核酸内切酶模式：在诊断和分子流行病学中的应用。
影响因子：
--
作者：
Roizman,B;Tognon,M
通讯作者：
Tognon,M