Comparative clinical characteristics among different age group of adult COVID-19 patients: A multicenter study.
Comparative clinical characteristics among different age group of adult COVID-19 patients: A multicenter study.
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不同年龄组成人 COVID-19 患者的临床特征比较：一项多中心研究。
DOI：
10.1002/iid3.550
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发表时间：
2022-03
期刊：
影响因子：
--
通讯作者：
Liao X
中科院分区：
文献类型：
--
作者：
Cheng W;Peng Y;Zhou A;Lin L;Liao X;Deng D;Huang P;Liu W;Jiang M;Xiang X;Shuang Q;Cai S;Chen P;Liao X
冠状病毒病（COVID-19）是一种全球性传染病，带来巨大的疾病负担和高昂的医疗费用。本研究旨在比较不同年龄组的成人 COVID-19 患者的临床特征。 2019年12月31日至2020年3月8日从邻近城市获得的实验室确诊的成人COVID-19感染病例。患者被分为五个年龄组。比较不同年龄组的临床特征。在 299 例病例中，中位年龄为 44 岁，其中 158 例 (53%) 为男性。 30~40岁占53.3%、40~50岁占50%、<30岁占36.6%、50~60岁占36.2%为原发病例，无老年人为原发病例。在所有观察到的症状中，只有呼吸困难症状在老年组与其他组之间存在显着差异(p<0.001)。年龄<30岁、30-40岁、40-50岁、50-65岁、≥65岁患者中重型或危重型比例分别为2.4%、5.3%、9.5%、14.5%和35%。累计治愈出院285例（95.3%），仍在院治疗12例（4.0%）。有 2 例（0.7%）死亡发生在 65 岁以上的人群中。有慢性心脏病史的患者患严重或危重型 COVID-19 的风险比没有慢性心脏病史的患者高 56 倍以上（比值比 [OR]：56.038，95% 置信区间 [CI]：2.764–1136.053，p = .009）。高龄（OR：1.055，95％CI：1.016–1.095，p = .006），入院时心率高（OR：1.085，95％CI：1.03–1.144，p = .002），入院时呼吸频率高（OR：1.635，95％CI： 1.093–2.431，p = .017）与 COVID-19 的严重或危重类型独立相关。重症或危重症的比例随年龄增长而增加。年龄较大、入院时心率、呼吸频率高以及有慢性心脏病史的成年人与 COVID-19 的重症或危重症类型相关。本研究旨在比较不同年龄组的成人 COVID-19 患者的临床特征。在所有观察到的症状中，只有呼吸困难症状在老年组与其他组之间存在显着差异。高龄、入院时高心率、入院时高呼吸频率以及慢性心脏病史与严重或危重独立相关。
Coronavirus disease (COVID‐19) is a global infectious disease with a large burden of illness and high health care costs. This study aimed to compare clinical features among adult COVID‐19 patients in different age groups. Laboratory‐confirmed adult COVID‐19 infection cases between December 31, 2019 to March 8, 2020 obtained from Neighboring Cities. Patients were divided into five age groups. Clinical characteristics were compared among different age groups. Of 299 cases, median age was 44 and 158 (53%) were male. A total of 53.3% of 30–40 years, 50% of 40–50 years, 36.6% of <30 years and 36.2% of 50–60 years were primary case, none of the elderly were primary case. Among all the observed symptoms, only symptom of dyspnea was significantly different between the elderly group and other groups (p < .001). Proportion of severe or critical type was 2.4%, 5.3%, 9.5%, 14.5%, and 35% in patients with age <30, 30–40, 40–50, 50–65, ≥65, respectively. A total of 285 patients (95.3%) were cured and discharged, 12 patients (4.0%) were still on medical treatment in hospital. There were 2 (0.7%) deaths which occurred among persons ≥65 years. Patients with a history of chronic heart disease had a more than a 56 times higher risk for severe or critical type of COVID‐19 than those without a history of chronic heart disease (odds ratio [OR]: 56.038, 95% confidence interval [CI]: 2.764–1136.053, p = .009). Old age (OR: 1.055, 95% CI: 1.016–1.095, p = .006), high heart rate in admission (OR: 1.085, 95% CI: 1.03–1.144, p = .002), high respiratory rate in admission (OR: 1.635, 95% CI: 1.093–2.431, p = .017) were independently associated with severe or critical type in COVID‐19. Proportion of severe or critical type increased with old age groups. Adults with old age and high heart rate, respiratory rate in admission and history of chronic heart disease were associated with severe or critical type in COVID‐19. This study aimed to compare clinical features among adult COVID‐19 patients in different age groups. Among all the observed symptoms, only symptom of dyspnea was significantly different between the elderly group and other groups. Old age, high heart rate on admission, high respiratory rate on admission, and history of chronic heart disease were independently associated with severe or critical.
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影响因子：
2.4
作者：
Prajapat M;Handa V;Sarma P;Prakash A;Kaur H;Sharma S;Bhattacharyya A;Kumar S;Sharma AR;Avti P;Medhi B
通讯作者：
Medhi B
DOI：
10.1111/jth.14817
发表时间：
2020-05
期刊：
Journal of thrombosis and haemostasis : JTH
影响因子：
--
作者：
通讯作者：
--
影响因子：
3.2
作者：
Wang L;Green FH;Smiley-Jewell SM;Pinkerton KE
通讯作者：
Pinkerton KE
影响因子：
6.1
作者：
Liu Wei;Tao Zhao-Wu;Hu Yi
通讯作者：
Hu Yi
影响因子：
11.8
作者：
Marrie, TJ;Carriere, KC;Johnson, DH
通讯作者：
Johnson, DH